Earlier quoted context omitted.
If you're prepared to toss ethics overboard it's not that hard to come up with significant, relevant and valid results. The whole trick is to get those results while acting ethical.
I think there's another issue that being willing to be completely unethical requires such distorted thinking (for humans, anyway) that it introduces its own sort of spurious results. Just thinking about a lot of callous and inhumane psychobabble that was promulgated not too long ago, mostly dealing with people whom the researchers thought of as not-quite-as-human.
http://www.zdnet.com/article/facebook-unethical-untrustworth...
And like in that study (which went so far as to actively mess with the subjects emotional states) I miss the 'consent' element.