I've lost at least two elderly, extended family members this way. Both applied both a patch and took a pill, which caused an OD.
The issue is that many opioids and non opioids gap between the therapeutic dose range and LD50% is often dangerously narrow.
Complication #0: serum bioavailable molecule assay is rarely monitored. People metabolize and clear drugs at vastly differently rates.
Complication #1: Hospital mistakes still happen quite frequently, despite many measures to prevent them, especially with inexperienced and overworked nurses/assistants.
Complication #2: cummulative dosing error or interactions, especially multiple, independent prescriptions for similar opioids with different administration routes (patches, sprays, pills, injections)
Complication #3: overprescription of opioids because they're cheap, especially to veterans, which also leads to prescription and hard drug addictions.
Solution: opiods need to be singularly controlled at home or in the hospital by an integrated, blood/interstitial fluid measuring/dispensing unit to avoid OD and push back on abuse.
Plus, anyone taking opioids should also have narcan or equivalent antidote readily available, and wear a medalert QR code bracelet which lists relevant conditions and medications should they be found unresponsive.
Finally, avoid painkillers as much as possible and take the least dose which reduces stress level.