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Research into ketamine as a treatment for severe depression

washingtonpost.com

21–30 of 58 posts

Re: Research into ketamine as a treatment for severe depression

#21
post #17

Earlier quoted context omitted.

Is that the side of the Atlantic that has serious problems with binge drinking of alcohol?

No - the side that has a sense of humour.

and I've been to New York, Boston and Cancun you can't tell me there isn't binge drinking over there too. sap.

Re: Research into ketamine as a treatment for severe depression

#22

Earlier quoted context omitted.

No - the side that has a sense of humour.

and I've been to New York, Boston and Cancun you can't tell me there isn't binge drinking over there too. sap.

While I'm at it: http://www.newyorker.com/news/john-cassidy/why-is-the-death-...

Re: Research into ketamine as a treatment for severe depression

#23

Earlier quoted context omitted.

and I've been to New York, Boston and Cancun you can't tell me there isn't binge drinking over there too. sap.

While I'm at it: http://www.newyorker.com/news/john-cassidy/why-is-the-death-...

This is a lot of butthurt for getting smacked down for a stupid joke. Let it go. Save your jokes for reddit.

Edit: slur? WTF?

Re: Research into ketamine as a treatment for severe depression

#24
post #8

Here is anecdotal evidence for another interesting "drug": http://www.ncbi.nlm.nih.gov/pubmed/16542786 In this study, N=small, but nevertheless, I think it is a very interesting article. Because the effects are so rapid, and magnesium supplementation is in general harmless, it is imho definitely a good idea to see if a magnesium deficiency is the cause of the disorder. Please take note that not all magnesium suppleme…

Technically, it's not a study. They present a few case histories, which is basically, "we found a few patients whose depression went away after taking magnesium, maybe we should look into it".

That being said, it would be pretty easy to investigate.

Re: Research into ketamine as a treatment for severe depression

#26
post #11

Earlier quoted context omitted.

I have only been moderately depressed, and I have no experience with this particular treatment... but I have had experiences that for a few hours swept away my anxiety, poor self-image, and so on. Metaphorically, it's been like opening a window for someone who's been stuck in a basement. Even without extreme euphoria—just a simple sense of contentment, like nothing is very wrong—that's such a revelation. A big part o…

> So however you find it, just a couple of hours of, say, having a conversation where you don't feel like the worst loser in the universe and the nadir of civilization, that just shows you something about life. It really would have been nice for me while i was a child. yes. i should have been given ketamine as a child. my depression was so bad for most of my life that i could count the days where i didn't feel depres…

You write as if it's all past tense for you. How did you end up getting better?

Re: Research into ketamine as a treatment for severe depression

#27
post #12
post #5

While this is undeniably impressive and hopeful, it should be noted that these are short-term affects. The article mentions this: "So far, there is no evidence of addiction at the low dose in which infusions are delivered. Ketamine does, however, have one major limitation: Its relief is temporary. Clinical trials at NIMH have found that relapse usually occurs about a week after a single infusion." It then goes on to…

> First, when my depression gets really acute it basically means that I simply am unable to leave the house. You also would not really want to leave the house on Ketamine.

This isn't while high on ketamine, this is about the week following, when your brain is still feeling the after effects in a positive way. Proper depression fucking sucks -- it's not just about feeling sad, you get to a place where your body aches, and even getting the motivation to go across the room to get meds seems almost more trouble than it works. Depression is not just feeling sad, there are a lot more symptoms involved, and if it means needing a day out of seven to not go outside, that's still a lot better than only being able to go outside one to two days in seven.

Re: Research into ketamine as a treatment for severe depression

#28
post #5

While this is undeniably impressive and hopeful, it should be noted that these are short-term affects. The article mentions this: "So far, there is no evidence of addiction at the low dose in which infusions are delivered. Ketamine does, however, have one major limitation: Its relief is temporary. Clinical trials at NIMH have found that relapse usually occurs about a week after a single infusion." It then goes on to…

> Clinical trials at NIMH have found that relapse usually occurs about a week after a single infusion."

But if you read till the end, they say that Hartman has to get booster shots every 6 months or so:

> These days, he says that his periods of remission between infusions often stretch to six months.

Re: Research into ketamine as a treatment for severe depression

#30
post #12
post #5

While this is undeniably impressive and hopeful, it should be noted that these are short-term affects. The article mentions this: "So far, there is no evidence of addiction at the low dose in which infusions are delivered. Ketamine does, however, have one major limitation: Its relief is temporary. Clinical trials at NIMH have found that relapse usually occurs about a week after a single infusion." It then goes on to…

> First, when my depression gets really acute it basically means that I simply am unable to leave the house. You also would not really want to leave the house on Ketamine.

They aren't prescribing recreational doses, he would be perfectly functional and experience no dissociation whatsoever, it's something the drug community has been talking about for a long time.

Lookup "microdosing" if you're interested, a lot of people do it with dissociatives or psychedelics and the point of it is to a below threshold dosage and avoid the typical drug high.

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