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Ask HN: What should we fund at YC Research?

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351–360 of 545 posts

Re: Ask HN: What should we fund at YC Research?

#351
STEAL IDEAS FROM OTHER LIFEFORMS BEFORE THEY DIE OFF Which organisms are we most likely to benefit from stealing ideas from? Can we prevent them from going extinct before we get to learn those ideas? Is there a way to capture the ideas pre-extinction? Even the tools that we now have to change the blueprints of life, we stole from life. Bateria and Viruses are the source of our most powerful DNA editing tools currently. We are meat. Animals are meat. The animals have all kinds of amazing tricks and tools their meat has developed. We could use some of their tools. If they become extinct, we can't learn well from them any longer. If you want to take advantage of the millions of years of building with the best tools we're aware of, real evolution over long time periods, and you don't want to wait for a couple million or hundred million years for the next go round of that thing maybe evolving again, then you should try to prevent extinction of the organisms most useful to learn from for our own benefit.

MINIMUM VIABLE EDUCATION What is the minimum effective dose of teachable knowledge/skill. Input, process, output. ala grammar, logic, rhetoric, trivium fame.

Success leaves clues. The most effective often have little mental tricks they apply when thinking, some are mnemonic, some are turning ideas into locations, some are pretending new ideas are just like old ideas, and applying the old learnings, etc. Find those powerful commonalities.

Stop making kids bad versions of google. We don't need more bad data storage in human minds, we need more of what the machines can't do yet, creativity, love.

If you must make kids bad versions of google and shove facts into them for lossy storage, then at least teach them mnemonic technique and logic first, google-fu, so as to amplify all their future efforts. Do not teach the amplifiers last, let them pay dividends over time. I was lucky enough to have logic tought to me first before any other maths at grade 6, because of an experimental advanced education system. After logic we learned scheme programming. I think those frameworks greatly helped me in this life, as nesting of ideas and good data processing is super powerful in all areas of life.

Better and worse exist, find better, choose better. Do not be a coward and pretend that worse doesn't exist.

summary: teach amplifiers first. Then teach minimum effective commonly useful data processing, then specialize and become great.

Specialization is why we have genders. Dimorphism lets us not over-allocate excellence in a single place at the cost of another place. Great things come from specialists. If the value of skill is in opposite proportion to supply of that skill, then everyone learning the same things, by definition means no one will pay for that skill or knowledge. There's some exclusions to that idea, such as language itself, however the theme of slapping knowledge/skill on a supply/demand curve is a good one. Much of this idea is hammer in Peter Thiels 0-1. less 1 to 1 horizontal iteration and more 0 to 1, no one else is working on this thing kind greatness.

What is minimum effective curriculum before specializing? What is the minimum viable education? What is the correct execution order of those skills?

For instance, how important is it to teach kids to write essays, when they actually don't have much useful to say? Maybe you should work on having useful things to say much harder before you learn how to beautifully say them. Imagine that you did the opposite, imagine that you taught effective rhetoric before logic, and now you've got better salesmen of bad ideas. That's worse, not better. Think of the places in the world where women aren't allowed to drive cars. How did that terrible situation arise? Great marketing of terrible ideas.

Re: Ask HN: What should we fund at YC Research?

#353
Small research grants for students/independent researchers.

I'd suggest something like 5k for a 3 months project. Applicant has to hand in a short proposal in the beginning and publish his code/data/results as open source. There are many great research ideas to work on independently today (e. g. in AI), but it's pretty much impossible to get money/recognition for that. For example, such a program would enable students to work on their own idea during the summer break (and in some cases produce something valuable for others), instead of doing some meaningless stuff at an internship.

Re: Ask HN: What should we fund at YC Research?

#354
post #129

http://sens.org/ . Humans need more lifespan, badly. I’d have said AI safety, but it’s already on your list. Excellent. I’d also have said basic income. Good to know you’re on it. Meta-research. Academic publishing is obsolete, and knowledge should not be paywalled. How many researchers already make use of https://www.reddit.com/r/scholar or http://sci-hub.io/ ? Bacteriophages. Antibiotics are running out, while phag…

> Academic publishing is obsolete To expand upon this, it's not just publishing papers behind paywalls that is the problem. The entire system we use to advance humanities shared knowledge is broken. The Internet enables a dramatically more efficient model of scientific collaboration. The problem is academic science has been stuck with a reward system from the 17th century. And quite simply, it does not reward what we…

Can we add some nuance here? It is not like in the last few decades there has been no new knowledge generated.

Just in my own field of biology, the amount of progress we have made in understanding how cells regulate themselves (20 year ago we were still teaching DNA->RNA->PROTEINS that do stuff), how immune systems function and can be used (stem cell therapy, cancer treatments, HIV drugs) and the flow of genetic information between organisms (the advance of (whole) genome sequencing into becoming a generic tool) has been mind-boggling.

Re: Ask HN: What should we fund at YC Research?

#355
post #334

Earlier quoted context omitted.

> Or do we need more realistic perspective about death? We do: we need to realize how horrible it is that we treat it so casually, rather than as a tragedy. Perhaps then we'll do something about it. > [1] Notice that cancer, heart-disease, Alzheimer, etc research also falls into this category - allowing people to live with less suffering. All three of which (especially the first and last) have heavy ties to aging. It…

Wanting to live forever has to be the apex of egoism and arrogance and all that is wrong with the human mind. Death is good because it leaves room for new people with new ideas. Being against death reveals a profound misunderstanding about what life is about, which is: finiteness, urgency, novelty, creativity.

Agreed.

Something I've been thinking about for a while is: what would it mean for peoples' willingness to save another person from a burning building, or swim to rescue someone drowning at sea, or donate a kidney, etc, if we all developed a sense of entitlement that we should be able to live forever?

When so many people at all levels of society are unable to enjoy the lives they have, I feel that life extension research is not something that should be a high priority for investment.

Re: Ask HN: What should we fund at YC Research?

#358
Research into off label uses of unpatented drugs.

(Inspired by the article recently posted here which pointed out that although a drug is being used off label to treat phobias, there is no incentive for a company to get that use certified.)

Re: Ask HN: What should we fund at YC Research?

#359
Vasalgel, a 100% effective, permanent but (hopefully) fully reversible non-surgical, non-hormonal male contraceptive. It's a variation of the Indian RISUG formulation, being pushed through the US testing gauntlet by a non-profit organisation. They're specifically looking for "social investors" at this time as they approach clinical trials:

> But now that Vasalgel has passed the “proof of concept” phase, it’s time to kick it up a notch — without selling out or losing the social mission of affordability and wide availability. We’re starting an all-out push to hire top medical device people and bring in social investors interested in both moving things forward quickly, and in keeping the end result affordable.

http://www.parsemusfoundation.org/contraceptives/clinical-tr...

Re: Ask HN: What should we fund at YC Research?

#360
post #221

Earlier quoted context omitted.

> Or do we need more realistic perspective about death? We do: we need to realize how horrible it is that we treat it so casually, rather than as a tragedy. Perhaps then we'll do something about it. > [1] Notice that cancer, heart-disease, Alzheimer, etc research also falls into this category - allowing people to live with less suffering. All three of which (especially the first and last) have heavy ties to aging. It…

Interesting. Would you do it for animals too? It would suck to live for 400 years but your dog dies in only 10. How would people remember everything? How would you spend all that time? What would everyone do? Is this just for rich people or do poor people get to live for centuries too? Haven't done the math but if 8 billion people lived for say 500 years each, plus new arrivals constantly, wouldn't we accumulate rath…

Therapies after the SENS model will be mass-produced infusions (gene therapies, small molecule drugs, etc) coupled with some personalized stuff based on growing cells from a cell sample. It will be the same treatment for everyone, and subject to economies of scale that are the same as for today's drugs. Most will cost a few dollars per treatment after being in circulation for a few decades, the same as mass produced generic drugs today, and 30 years further into autologous stem cell therapies, those also will cost a lot less than the few thousand that they do now.

People have done the modeling on what radical life span does to population growth. The answer is a lot less than you think. See: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3192186/ "For example, we applied the cohort-component method of population projections to 2005 Swedish population for several scenarios of life extension and a fertility schedule observed in 2005. Even for very long 100-year projection horizon, with the most radical life extension scenario (assuming no aging at all after age 60), the total population increases by 22% only (from 9.1 to 11.0 million)."

Most of the objections of the type that you voice can be answered by moving you to 1850 and making the same objections to the progress of medicine, and then seeing that they are obviously false concerns given where we are today. You could argue in 1920 that the same objections exist to building treatments that prevent people dying from heart disease: isn't it just for rich people, won't there be too many people if the old don't die on time, what would they do with all those extra years, isn't the present length of life just right, etc, etc.

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