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Ask HN: What should we fund at YC Research?

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Re: Ask HN: What should we fund at YC Research?

#281

Explore game theoretically sound ways to start new companies as "worker co-ops" and to reward participants. The idea being to aim toward a future where there is a large gray area between "employee" and "entrepreneur." The companies formed don't have to be start-ups per se: they could be as simple (and low risk) as a group of people who build web sites and apps for clients, but would like to have a stake in it rather…

I worked this out in great detail, it took about a decade to get the bugs out. The problem is that it works well for founders and other people interested in the mechanics of running a company but it emphatically does not work for people who would rather 'just be paid'. Not everybody wants to be an active participant in the ownership portion of a company, plenty of people simply want a job and a paycheck and that's it…

I have no doubt there are people who would rather just be paid, probably the majority of people. But that still leaves a lot of people to do this sort of thing.

Also, as the companies grow a bit larger and mature, they should be fine for the "just want to be paid" folk, as that is basically how it would work.

Also, I would hope that most of the mechanics would just be handled by the system. At least the tedious stuff. Stuff like voting on company/product direction, and rating your peers seems like something everyone would like to participate in, especially if it doesn't become political (in a bad way).

Re: Ask HN: What should we fund at YC Research?

#282
post #129

http://sens.org/ . Humans need more lifespan, badly. I’d have said AI safety, but it’s already on your list. Excellent. I’d also have said basic income. Good to know you’re on it. Meta-research. Academic publishing is obsolete, and knowledge should not be paywalled. How many researchers already make use of https://www.reddit.com/r/scholar or http://sci-hub.io/ ? Bacteriophages. Antibiotics are running out, while phag…

> Academic publishing is obsolete To expand upon this, it's not just publishing papers behind paywalls that is the problem. The entire system we use to advance humanities shared knowledge is broken. The Internet enables a dramatically more efficient model of scientific collaboration. The problem is academic science has been stuck with a reward system from the 17th century. And quite simply, it does not reward what we…

I agree completely about the system being broken and that innovation would be fantastic (I wrote a few paragraphs below, but in a very different direction). I'll take a close look at Thinklab, and it'd be great to see a dialogue forming here.

Re: Ask HN: What should we fund at YC Research?

#283
post #269

Earlier quoted context omitted.

> Is this just for rich people or do poor people get to live for centuries too? "centuries" is far too short-term; "forever" is the goal, and "centuries" just buys enough time to get there. And of course that lifespan should be available to everyone. If the solution itself doesn't already imply a post-scarcity world, then it'll help that once you have a cure for aging, it's more economical to supply that to everyone…

If we cure aging and live for centuries we will still be subject to accidents while we are trying to work out how to live without a body at all. I would be interested to know how likely it is to get maimed or killed during this extended period and how it would affect the psychology of a person. I assume it would be a pretty frightened bunch not leaving home much.

One of several rough estimates I've seen suggests that if you eliminated all biological causes of death, and left only accident and similar, that would bring the average lifespan to around a thousand years. Producing such an estimate seems straightforward enough, given statistics about causes of death.

As for how that might affect psychology: honestly, I'd love to see how the world might change if people adopted drastically different attitudes towards death, but I don't think it likely that this would produce far more risk aversion than we have today. Not least of which because I see no signs of tobacco companies going out of business.

For myself personally, I'm not going to stop leaving the house, but I certainly have no intention of taking up hobbies like hang gliding or motorcycle racing, any more than I plan to start smoking. (Side note: for an interesting measure of risk, see https://en.wikipedia.org/wiki/Micromort) I don't think that level of risk aversion qualifies as "a pretty frightened bunch not leaving home much".

Re: Ask HN: What should we fund at YC Research?

#284

If everything goes, please research a viable way to open borders globally. Not only is there tremendous economic potential energy there, but national borders are sadly one of the few openly discriminating policies out there, a major source of inequality and injustice. I would love to see progress towards that end.

Global open borders would create chaos. Imagine if homes didn't have fences or doors and anyone can just walk in & out of your home.

Re: Ask HN: What should we fund at YC Research?

#285

Explore game theoretically sound ways to start new companies as "worker co-ops" and to reward participants. The idea being to aim toward a future where there is a large gray area between "employee" and "entrepreneur." The companies formed don't have to be start-ups per se: they could be as simple (and low risk) as a group of people who build web sites and apps for clients, but would like to have a stake in it rather…

There have been some attempts at this - assembly.com and one other company that I don't remember the name of. Has not worked out yet, as the contributors usually lose focus after a while

I wasn't familiar with assembly.com. I think that it would be a challenging thing to get right, so that such issues don't tend to occur, but it should be doable. One thing that is probably needed is people who join as project managers, to keep things on track and provide reports on each person's commitments, progress etc to other members (all of whom can rate the contributions of one another). When starting out that may not be necessary, but after it starts to gain momentum you may well need some additional help to keep the momentum going.

Re: Ask HN: What should we fund at YC Research?

#286

My wishlist in no specific order. You should consider crowdfunding some of the research- I would be interested in options to support these kind of issues and I'd have no issue with the results being commercialised provided there was some form of "open sourcing" the technology. * Green energy * Battery technology * Water cleansing (ie pollutants from rivers & oceans * Water purification * Air purification * Food produ…

Nice list! Has some similarities to mine.

Re: Ask HN: What should we fund at YC Research?

#287
Life is quality x quantity. Quality is far into diminishing returns. Quantity can be 10x'd. The best in their fields die, right when they're most useful. What would Edison, Tesla, Franklin, Bell, Feynman, etc be producing currently if still alive?

Since quantity is literally the hardest problem we are aware of, how shall it be attacked? By charity? Let's be serious, look around yourself right now, point to the things charity created. Now cease the futile exercise.

Solution: 1. Marketing as gates does, however all lives are not worth the same, you, your kin, your friends, they are worth more. Fund the research that saves them, do not dream the silly dream that all lives are worth the same.

2. Profit not charity, i.e. take a look at osfund.co (human longevity, inc) sustain and grow, not charity and run out of runway.

3. LONGEVITY FUND. or "save your assssssssets fund" You can buy the S&P500 why not the biotech index minus the companies solving problems you won't have. Reduced malaria drug allocation, increased cancer and heart disease. Guess what. If you survive malaria, you are still going to die of cancer and heart disease, so lets work on those 40 and 40 percent killers.

I've got 220k words on paper. 1. 1st book, personal excellence, things you can do to Scivive. Get rich, be loved, live forever… *if selling ideas is good enough for Bill Gates, e.g. Gatesnotes.com, givingpledge.org, its good enough for me, and you. Spread the word. This genre seems easier to understand.

2nd book, things that are important, however are rarely actionable in your personal sphere of influence (politics, currency, voting, economics, geopolitics, environment, interesting yet un-actionable for the common man things.

3. Longevity fund. biotech index minus things unlikely to be useful in saving you and your loved ones lives.

4. Companies not a subset of Nasdaq biotech index, too small, or in a different jurisdiction.

5. Biotech/synbio startups.

6. Popularity improvement ala "The Martian" whereby science and tech becomes heroic as kicking aliens in the face has been historically. The world need not hero worship the leather ball throwing and kicking, steel lifting and lowering, non scaling great strategies of 2,000 years ago. Let's make heroic the things that actual work these days. How many humans can you heal? Can you save thyself and thy family?

If anyone wants to help edit these 200k+ words I have on the page regarding life and winning at it, hit me at Scivive on gmx.com

P.S. Spread great actionable ideas (sell SP500 buy biotech index.), fund excellence, build excellence, fund riskier excellence in that order.

Re: Ask HN: What should we fund at YC Research?

#289

Earlier quoted context omitted.

hence the research. Yes - I have been following people like Layne Norton, Lyle Macdonald, etc. for years. And Crossfit has a huge number of critics for its program. It would be see results of research on a safer, better program/diet.

But even people who read research diligently (like Lyle) are only as informed as the research is accurate. Look back to what Lyle was writing 16 years ago (strict caloric arithmetic, the discovery of leptin will make dietary obsessions obsolete, microbiome doesn't matter, etc.)

agreed - which is why I think YC should spend on fitness/nutrition research.

I personally think this has the potential to be a moonshot - if an unbiased entity (with no ties to entrenched interests) would spend money on research.

Re: Ask HN: What should we fund at YC Research?

#290
Burnout.

YCR should fund a longitudinal study of a cohort of say 100 entrants into the tech field, and watch them over the course of 4-5 years. Periodically subjecting them to fMRI scans. Of particular interest would be the relationship of motivation/reward pathways (I'm thinking the striatum) during the transition through burnout. Burnout could be quantitatively measured through techniques such as tracking with body motion trackers, etc.

A follow-up study could attempt to use knowledge gained in this with several treatment strategies.

SamA: If you are interested in something like this I know the right researcher, she has incredible scientific integrity, IMO important for cogsci/socsci research especially of late, although she and I have not been in personal touch for years.

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