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Antioxidants May Make Cancer Worse

scientificamerican.com

31–40 of 42 posts

Re: Antioxidants May Make Cancer Worse

#31

The article just talks about antioxidant supplements being harmful, not naturally occurring antioxidants from sources such as coffee. That's good. Don't ruin coffee for me, please science. I don't really understand the whole supplement craze. To me, it feels like common sense not to megadose any particular thing, especially when you don't understand the effects said thing can have on the body.

"Polyphenols in coffee have been shown to affect free radicals in vitro,[132] but there is no evidence that this effect occurs in humans. Polyphenol levels vary depending on how beans are roasted as well as for how long. As interpreted by the Linus Pauling Institute and the European Food Safety Authority, dietary polyphenols, such as those ingested by consuming coffee, have little or no direct antioxidant value following ingestion."

https://en.wikipedia.org/wiki/Coffee#Health_and_pharmacology

It's very hard to trust health information you get from the news.

Re: Antioxidants May Make Cancer Worse

#32
post #3

Reductionist science does it again.

Reductionist science or reductionist science reporting?

I think it's fair so say the idea that ingesting more antioxidants will cause there to be more in your cells despite homeostasis can be fairly called overly reductionist science. Science reporting in this case failed by essentially taking a side before the experiments came in and not backtracking afterwards.

Re: Antioxidants May Make Cancer Worse

#33
post #19

Years ago (10ish) I read an article (that I've tried to find a few times since, but failed) by a researcher that tried to find the studies that said antioxidants were good for you. He traced stories and articles back to... nothing. I think the first mention he found was in a popular magazine and it had no data or research to back it up. I really wish I could find that article again. I remember being fascinated by it.…

Antioxidants play a role in absorbing free radicals, which are unpaired electrons sitting on organic compounds inside the cell.

Free radicals are not entirely stable, and are mutagenic when they attach and break the phosphate molecules in the backbone of DNA (possibly leading to cancer).[1] These are dangerous because they can form reaction chains, which break molecule after molecule before finding a resting state. The antioxidants tend to give a more-stable resting state for the free radical, which makes it easier for your body to clear it.

Hence if your body has enough free-radical fighting antioxidants, it is more equipped to metabolize cancer-causing compounds.

[1] http://www.ijpsr.info/docs/IJPSR10-01-03-04.pdf

Re: Antioxidants May Make Cancer Worse

#34
The title should have been "Some molecules, which happen to be antioxidants, may cause cancer".

In no way does the research suggest that the antioxidant characteristics of the molecules are what is causing the cancer.

Re: Antioxidants May Make Cancer Worse

#35
post #19

Years ago (10ish) I read an article (that I've tried to find a few times since, but failed) by a researcher that tried to find the studies that said antioxidants were good for you. He traced stories and articles back to... nothing. I think the first mention he found was in a popular magazine and it had no data or research to back it up. I really wish I could find that article again. I remember being fascinated by it.…

Distilled, the article basically offer the contention that:

>.... it “could be that while antioxidants might prevent DNA damage—and thus impede tumor initiation—once a tumor is established, antioxidants might facilitate the malignant behavior of cancer cells..."Then immediately says this:

>The medical advice for people at this point is tentative. More studies need to be done to bolster this hypothesis and understand exactly how antioxidants affect cancer cells in humans. My takeaway is this:

Antioxidants may help prevent the sorts of DNA damage that contribute to cancers forming... Antioxidants may contribute to the health of cancer cells, once formed, in much the same way...but that's not certain yet, even though it certainly seems plausible...

In actual practice--everyday life--we have no idea at any given time whether we have active cancer cells growing in our body, or not...symptoms are what lead us to suspect that such is the case and seek medical advice...with certain types of cancer symptoms can take months, years, to appear...if the contention is true it's possible that people are going out of their way (with supplements), or being obsessive (with diet), all the while unknowingly contributing to their undoing...

I think I'll just keep eating a healthy blend of foods, avoid all supplements unless they've been prescribed because a diagnosed deficiency, and get plenty of exercise...

Re: Antioxidants May Make Cancer Worse

#36
I remember reading a comment somewhere (HN? Slashdot?) years ago that talking about the mechanisms behind antioxidants. The gist was that antioxidants would help prevent cancer, up until the point where cancer manifests itself. After that, it would actually help cancer.

Note that the comment was speaking from a critical thinking perspective about the way cancer works and the way that the antioxidants work in the body (not from actual study results).

So this doesn't seem so surprising to me.

Re: Antioxidants May Make Cancer Worse

#38
post #2

As I am now on my second Melanoma (luckily stage 1) this article hit me right in the stomach for some reason. I kept looking to see if I am eating something wrong. So can someone with better understanding of antioxidants explain if this is only via vitamin or if it's specifically present in some types of food.

Methionine restriction might be worth looking into:

http://www.ncbi.nlm.nih.gov/pubmed/22342103

Re: Antioxidants May Make Cancer Worse

#39
post #19

Years ago (10ish) I read an article (that I've tried to find a few times since, but failed) by a researcher that tried to find the studies that said antioxidants were good for you. He traced stories and articles back to... nothing. I think the first mention he found was in a popular magazine and it had no data or research to back it up. I really wish I could find that article again. I remember being fascinated by it.…

That link states, "While it’s true that the package of antioxidants, minerals, fiber, and other substances found naturally in fruits, vegetables, and whole grains helps prevent a variety of chronic diseases..."

However, has even that much been proven? We know eating fruits and vegetables is good for you, and we know that in vitro, antioxidants help prevent damage to cells from free radicals. But considering that experiments with antioxidant supplementation have failed, do we really know that it's the antioxidants in fruits and vegetables that make them good for you?

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