Is serotonin the happy brain chemical?

> they usually show it is actually less "toxic" than alcohol.

That's not saying much. A jab in the eye with a sharp stick is less toxic than alcohol, but it's not a good idea.

I've noticed a strong pop-psych trend these days of referring to one's own feelings or experiences in terms of neurotransmitters. e.g. "I'm hooked on the dopamine rush of such-and-such activity," "I'm feeling blue today, my serotonin must be low," etc.

This drives me crazy. It's pure pseudoscience, and I hear it from people who should know better. Scientifically, we have very little idea what chemicals are actually behind different subjective feelings/moods/whatever. Everyone would love to believe that the brain operates in a simple, intuitive fashion, with one chemical for joy, one chemical for sadness, one chemical for anger, etc., but the reality is way more complex and nuanced.

For example, even something well-studied like dopamine, which has been strongly linked with the brain's addiction circuitry, doesn't necessarily stimulate any sort of direct pleasurable feeling as people often infer. It seems to work in a much subtler way, modulating learning, attention, and goal-seeking behavior. A recent study found that it doesn't even necessarily spike when good things happen, but tends to increase in response to unexpected events, good or bad.

I can't speak for MDMA, but I have experimented (ok, recreated) with psilocin (shrooms), 4-ACO-DMT, and DMT, which are all serotonin agonists.

The best I can describe it is that a high enough dose feels like putting your brain into debugging mode and then cycling through hundreds of circuits simultaneously. It's not so much "I am experiencing happy now" as "I am experiencing happy, sad, confused, interested, pulsating colors, fractals, childlike wonder, fear, and every other cognitive state simultaneously or in rapid succession."

Some people get very spiritual about it, but I think you kind of have to be a spiritually inclined person anyway to have that specific experience. I always saw it more of giving the hardware a good jolt and seeing what falls out. It's pretty common to go from laughing uncontrollably, to inconsolable sadness, and back again, fairly quickly. This is where a lot of the fear about "bad trips" comes from, but I've found you can manage that with practice and having experienced people tripping with you or babysitting.

I do think there are therapeutic benefits though. Even if there are difficult periods, I find I always felt happier, more ok with the world and open to new experiences and attitudes for up to weeks after words. The article briefly mentions how there's a hypothesis that depression is possibly an effect of individuals who "over learn" negative experiences and become fixated on negative outcomes, and this makes a lot of sense to me. Aside from a sort of "purging" feeling just from such intense bursts of emotions, I could see how it helped to kind of kick me out of the traps of negative and habitual thinking and emotions. Maybe it helped my neurons "relearn" there are other experiences, emotions, and modes of thinking that I can access too?

This is all anecdotal evidence though, gathered while under severe impairment, so take it with that caveat. I would bet that aside from the legal issues, the hardest part of investigating things like psychedelics in a scientific way is that every experience is inherently subjective and personal. Trying to describe and talk about them gets very squishy very quickly.

Why would you claim this? From what I have read 5-Hydroxytryptophan seem like a widely accepted supplement for issues with Serotonin and/or depression and mood. The only articles that I have found that say it might not be of use are studies that simply say that 5-HTP is better than placebo but that we can't say more yet because of lack of researches. Edit: and possible heart valves issues if you do not take it correctly

"5-Hydroxytryptophan (5-HTP), also known as oxitriptan (INN), is a naturally occurring amino acid and chemical precursor as well as a metabolic intermediate in the biosynthesis of the neurotransmitters serotonin and melatonin from tryptophan." (https://en.wikipedia.org/wiki/5-Hydroxytryptophan)

"Preliminary studies indicate that 5-HTP may work as well as certain antidepressant drugs to treat people with mild-to-moderate depression. Like the class of antidepressants known as selective serotonin reuptake inhibitors (SSRIs), which includes fluoxetine (Prozac) and sertraline (Zoloft), 5-HTP increases the levels of serotonin in the brain. One study compared the effects of 5-HTP to fluvoxamine (Luvox) in 63 people and found that those who were given 5-HTP did just as well as those who received Luvox. They also had fewer side effects than the Luvox group. However, these studies were too small to say for sure if 5-HTP works. More research is needed." (https://umm.edu/health/medical/altmed/supplement/5hydroxytry...)

etc, etc, burden of proof to you...

https://scholar.google.ca/scholar?q=5-Hydroxytryptophan&hl=e...

My "discontinuation syndrome" was coming off desvenlafaxine. My access to it was suddenly taken away so I had no choice but to sit through the brain zaps for probably a week or two. You can't be sure how long it's going to last and that shit is as unpleasant as it gets.