I make games in Unity/C#, and yes, of course it's slower than a custom C solution. But instead of spending time on writing my own containers and memory allocation, I spend time writing game logic. Instead of optimizing game to run from 100 to 150 FPS on my computer, I'd rather spend this productive time making 5 variants of the same game mechanic to find out which is more fun. Even if the game runs in just 30 FPS.
Of course, I sometimes try to research low-level stuff, write my own renderer, or do a small experimental project in pure C, but then my goal is to research, not to write a game. I can hardly imagine a project, where the goal would be to develop a game, and not to research, where using C and having to spend so much time on this matters would be a good trade-off compared to working on actual game mechanics in higher-level language.