Ketamine’s effect bolsters a new theory of mental illness
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Re: Ketamine’s effect bolsters a new theory of mental illness
#2I'm excited for there to be alternatives to SSRIs. I've never been diagnosed with depression, but my partner has and takes an SSRI. It certainly seemed to have a generally positive affect (totally subjectively), and relatively few negative side affects. That being said, having to take it every day sucks, and when she runs out, having forgotten to get it refilled, the mood affects are pretty terrible for us both. Hopefully this branch of research will continue and develop into a more positive alternative.
Re: Ketamine’s effect bolsters a new theory of mental illness
#3Ketamine is an exciting experimental approach for depression (especially with suicidal thinking) and anhedonia.
http://www.thelancet.com/journals/lanpsy/article/PIIS2215-03...
Researchers seem to be using an infusion of 5 mg per kg of body weight. That means you don't give a bunch of pills to a patient, which in itself helps a bit to reduce risk.
There's a bit of a web-based discussion here: https://www.youtube.com/watch?v=5b6zrpd1trk
Re: Ketamine’s effect bolsters a new theory of mental illness
#4This makes me nervous. Ketamine has major issues with bladder damage when taken repetitively.
Possibly with a low enough dosage this would be manageable, but speaking from experience from watching people that have been on the wrong end of the stick with this one. it can do some really serious long term damage in that department.
Re: Ketamine’s effect bolsters a new theory of mental illness
#5On the mechanistic side of things, http://www.pnas.org/content/112/26/8106.short is one of the more interesting papers to come out recently on ketamine's mode of action.
Re: Ketamine’s effect bolsters a new theory of mental illness
#6There are other drugs in the pipeline that have a faster onset of action than what is currently available, including GLYX-13 and NSI-189. I have taken NSI-189 and I can confirm that it works fast.
Re: Ketamine’s effect bolsters a new theory of mental illness
#7I'm excited for there to be alternatives to SSRIs. I've never been diagnosed with depression, but my partner has and takes an SSRI. It certainly seemed to have a generally positive affect (totally subjectively), and relatively few negative side affects. That being said, having to take it every day sucks, and when she runs out, having forgotten to get it refilled, the mood affects are pretty terrible for us both. Hope…
Also of note regarding SSRIs and pregnancy:
https://www.washingtonpost.com/news/to-your-health/wp/2015/1...
> A new study provides some of the strongest evidence yet that using an antidepressant like Prozac, Paxil or Zoloft during the final two trimesters of pregnancy may be linked to a higher risk of autism spectrum disorder for the child, but researchers said the results should be interpreted with caution.
Re: Ketamine’s effect bolsters a new theory of mental illness
#8This makes me nervous. Ketamine has major issues with bladder damage when taken repetitively. Possibly with a low enough dosage this would be manageable, but speaking from experience from watching people that have been on the wrong end of the stick with this one. it can do some really serious long term damage in that department.
They use a much smaller dose than is used recreationally.
Here's someone who was using 15 g per day: http://www.bbc.co.uk/newsbeat/article/29811499/k-bladder-the...
A therapeutic dose is 5 mg per kg. An average adult would be 80 kg, which gives a dose of 400 mg once every maybe 30 or 60 days.
Re: Ketamine’s effect bolsters a new theory of mental illness
#9I'm excited for there to be alternatives to SSRIs. I've never been diagnosed with depression, but my partner has and takes an SSRI. It certainly seemed to have a generally positive affect (totally subjectively), and relatively few negative side affects. That being said, having to take it every day sucks, and when she runs out, having forgotten to get it refilled, the mood affects are pretty terrible for us both. Hope…
Also of note regarding SSRIs and pregnancy: https://www.washingtonpost.com/news/to-your-health/wp/2015/1... > A new study provides some of the strongest evidence yet that using an antidepressant like Prozac, Paxil or Zoloft during the final two trimesters of pregnancy may be linked to a higher risk of autism spectrum disorder for the child, but researchers said the results should be interpreted with caution.
Also of note regarding SSRIs and causing pregnancy:
https://en.wikipedia.org/wiki/Selective_serotonin_reuptake_i...
> SSRIs can cause various types of sexual dysfunction such as anorgasmia, erectile dysfunction, diminished libido, genital numbness, and sexual anhedonia (pleasureless orgasm). Sexual problems are common with SSRIs. Poor sexual function is also one of the most common reason people stop the medication. Very rarely, these effects persist after discontinuation of the medication.
Re: Ketamine’s effect bolsters a new theory of mental illness
#10There are other drugs in the pipeline that have a faster onset of action than what is currently available, including GLYX-13 and NSI-189. I have taken NSI-189 and I can confirm that it works fast.
How did you happen to take NSI-189? Were you part of the phase 1 trial?