I haven't voted on your comment, but here's what stands out to me: (1) It's not written in good style. People who care about how their ideas are received by others take the time to write properly, including capitalization and punctuation.
(2) It reads like a middlebrow dismissal. It's critical but doesn't add much of substance on its own through the criticism. Wolfram certainly realizes that he hasn't proven his case, that current science is indeed incredibly useful, and that the current path will only be a "detour" if network- or automata-based models are proven correct in the end. That's why he says he "suspects" it "may" have led us to a detour. He certainly understands that the theory needs to be developed further. Put simply, Wolfram would probably agree with your overall sentiment, so the remarks are not insightful, but they're presented as if they'd likely be at odds with his position.
(3) Beyond style, the diction is unclear, such as the choice of the word "use-case". It's unclear to me what you're referring to. It's unusual to refer to physics as "use-cases". If that's intended as an analogy, then for me it doesn't connect or succeed.
(4) The ideas themselves are not clear. "... reveal those use-cases untouched by contemporary thought"; "an existence where every new finality conjures new questions". It's not clear what you're trying to convey with those phrases. You probably could say what you're trying to say in a simpler, more direct, and less critical way way. You might benefit from this advice: http://paulgraham.com/talk.html
> Here's a simple trick for getting more people to read what you write: write in spoken language. Something comes over most people when they start writing. They write in a different language than they'd use if they were talking to a friend. The sentence structure and even the words are different. [...] But perhaps worst of all [mistakes], complex sentences and fancy words give you, the writer, the false impression that you're saying more than you actually are.
If I was to try to rephrase what you've said in simple language, then I end up with something like: "The ideas need to work to be useful. We need to think up new ideas. I think we'll always have more questions to answer", which isn't that interesting. With the current phrasing it reads like a middlebrow dismissal.