Most epic problems are really social problems. That is, we know how to prevent and treat malaria, we have plenty of land and homes, we know how to prevent and treat AIDS, we have plenty of places for refugees to live, we know how to stop contributing to man-made climate change, etc.
Social problems need social solutions. That means a lot of people working together to enact or expand the solutions that we already know exist.
If you're super rich like Bill Gates, you can bring people together with money. The Gates Foundation funds a LOT of projects that employ a lot of staff and volunteers, and they market the heck out of them so a lot of other people know it's happening.
I'm not super rich, and neither are you. So we need to find ways to come together with other like-minded folks to push the rest of humanity to help fix the problem.
One way this happens is politics--run for office to attract popular support, or find a candidate who you agree with and support them.
But the real work of social change happens between elections, and the real platforms are not political parties, but mission-driven membership organizations. In the U.S. they're often called nonprofits, NGOs, institutes, foundations, etc.
So: want to make a difference on an epic problem? Find one or more mission-driven organizations working that problem, and get involved. Sign up for their alerts, give them money, go to events, share their social messaging, volunteer, or even go work for them.
I will say that the nonprofit world is, in general, well behind even big corporations when it comes to using software and technology. You know how the U.S. federal government has initiatives like the Digital Service and 18F to try to foster a modern tech mindset? Most nonprofits need that too.