Hacker News Board Hacker News, browsed like a classic message board
Live data from Hacker News

LSD Microdosing

rollingstone.com

Post reply on HN
Print view View original

31–40 of 48 posts

Re: LSD Microdosing

#31

Post by futuravenir »

dwiel wrote: post #30
futuravenir wrote: post #28

Earlier quoted context omitted.

I think you might be in dire need of some LSD if you can't imagine cutting up paper into small pieces.

The typical size of paper used to carry one dose is 1/4" square. Cutting that into 10 equal sized pieces would be relatively tedious. It also assumes that the LSD is distributed evenly across the paper.

https://gimletmedia.com/episode/44-shine-on-you-crazy-goldma... At around 20:30, she starts talking about the process. Take the piece of acid, dissolve it in water overnight. Drink 1/10th of the bottle of water. Or, y'know, an exacto knife and a ruler.

Re: LSD Microdosing

#32

Post by SirensOfTitan »

Mo3 wrote: post #19
thatswrong0 wrote: post #16

Earlier quoted context omitted.

There is no evidence that LSD is toxic to humans. It is, physically, one of the safest drugs you can take. Mentally is a different story, but at micro doses, you're hardly feeling the normal psychedelic effects that occur at recreational doses, so there's hardly potential for "bad trips". I'm guessing that micro dosing is perfectly healthy. The only problems are A) knowing what you're taking is LSD and B) knowing wha…

I am not talking about toxicity or bad trips, I am talking about your neurotransmitter systems. Permanent exposure to chemically altered levels and heavy fluctuations can and will change in you very negative ways and cause tons of problems nevermind the dose. I speak from experience.

Your anecdote isn't data here.

What do you mean by permanent exposure? Regular? If so, do you have any sources to back up your claim?

The right perspective here is that LSD is well tolerated by the human body, but we do not know what its effects are like when taken over a long period of time.

Re: LSD Microdosing

#33

Post by jhobag »

Mo3 wrote: post #22
burnte wrote: post #21

Earlier quoted context omitted.

You may speak from experience, but your data conflicts with tens of millions of people who have taken various psychoactive medications for a myriad of psychological conditions for decades, myself included.

I'm sorry but you're comparing apples and bananas here, friend. I'm pretty sure you're not being prescribed psychedelics or tripping off of your adderall. The mechanisms behind psychedelics are very poorly understood, as are most behind therapeutic psychoactive drugs but I am fairly certain that they are not the same.

burnte might be speaking of marijuana, as it is psychoactive

Re: LSD Microdosing

#34

Post by jhobag »

SirensOfTitan wrote: post #32
Mo3 wrote: post #19

Earlier quoted context omitted.

I am not talking about toxicity or bad trips, I am talking about your neurotransmitter systems. Permanent exposure to chemically altered levels and heavy fluctuations can and will change in you very negative ways and cause tons of problems nevermind the dose. I speak from experience.

Your anecdote isn't data here. What do you mean by permanent exposure? Regular? If so, do you have any sources to back up your claim? The right perspective here is that LSD is well tolerated by the human body, but we do not know what its effects are like when taken over a long period of time.

In general, serotonergic agonists at regular dosages definitely increase susceptibility to serotonin syndrome.

Re: LSD Microdosing

#37

Post by stevedekorte »

jhobag wrote: post #34
SirensOfTitan wrote: post #32

Earlier quoted context omitted.

Your anecdote isn't data here. What do you mean by permanent exposure? Regular? If so, do you have any sources to back up your claim? The right perspective here is that LSD is well tolerated by the human body, but we do not know what its effects are like when taken over a long period of time.

In general, serotonergic agonists at regular dosages definitely increase susceptibility to serotonin syndrome.

Aren't most anti-depressants" serotonergic agonists taken at regular dosages"?

Re: LSD Microdosing

#38

Post by uououuttt »

Mo3 wrote: post #19
thatswrong0 wrote: post #16

Earlier quoted context omitted.

There is no evidence that LSD is toxic to humans. It is, physically, one of the safest drugs you can take. Mentally is a different story, but at micro doses, you're hardly feeling the normal psychedelic effects that occur at recreational doses, so there's hardly potential for "bad trips". I'm guessing that micro dosing is perfectly healthy. The only problems are A) knowing what you're taking is LSD and B) knowing wha…

I am not talking about toxicity or bad trips, I am talking about your neurotransmitter systems. Permanent exposure to chemically altered levels and heavy fluctuations can and will change in you very negative ways and cause tons of problems nevermind the dose. I speak from experience.

I took average-to-high doses of LSD and/or other tryptamines nearly every day for 3-4 months. It did make me less able to function in my circumstances at the time (surprise surprise!), but I don't count the experience as negative overall, and given a different set of circumstances with fewer obligations to meet, it could have been wholly positive.

Re: LSD Microdosing

#39

Post by tkjef »

dwiel wrote: post #30
futuravenir wrote: post #28

Earlier quoted context omitted.

I think you might be in dire need of some LSD if you can't imagine cutting up paper into small pieces.

The typical size of paper used to carry one dose is 1/4" square. Cutting that into 10 equal sized pieces would be relatively tedious. It also assumes that the LSD is distributed evenly across the paper.

Tiny scissors, steady hand. Done.

However, yes, the distribution per piece may be off.

Re: LSD Microdosing

#40

Post by abrookewood »

uououuttt wrote: post #38
Mo3 wrote: post #19

Earlier quoted context omitted.

I am not talking about toxicity or bad trips, I am talking about your neurotransmitter systems. Permanent exposure to chemically altered levels and heavy fluctuations can and will change in you very negative ways and cause tons of problems nevermind the dose. I speak from experience.

I took average-to-high doses of LSD and/or other tryptamines nearly every day for 3-4 months. It did make me less able to function in my circumstances at the time (surprise surprise!), but I don't count the experience as negative overall, and given a different set of circumstances with fewer obligations to meet, it could have been wholly positive.

Jesus! Daily doses for months? How long ago? What do you mean by 'less able to function'? Any long-lasting effects?
Post reply on HN