I recently had one of those "time to tweak my environment" days where I spent the entire day trying out monospaced fonts (DejaVu Sans Mono, Bitstream Vera Sans Mono, Envy, Terminus... everything I could find) in various color schemes in multiple editors (Win). I've now pretty much set any program where I need a monospace font to Liberation Mono 10pt.
However, I think Consolas looks better if I'm trying to fit more onto the screen. It looks better at smaller sizes than Liberation.
So I've settled on using 2 editors most the time with pretty similar features (Notepad++ & Programmer's Notepad), one loaded with Liberation Mono, the other with Consolas for files where I'd like to squeeze more lines in and keep decent readability.
Maybe there's a better way of doing things, but I like having two sorta different workspaces that I can quickly open.