Vitamin C kills tumor cells with hard-to-treat mutation in mice
news.sciencemag.org
Vitamin C kills tumor cells with hard-to-treat mutation in mice
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Re: Vitamin C kills tumor cells with hard-to-treat mutation in mice
#2On a side note, Linus Pauling was notorious for, late in life, after winning all his Nobels and other such prizes, pushing the idea that megadoses of Vitamin C would cure all cancers: https://en.wikipedia.org/wiki/Linus_Pauling#Medical_research...
https://www.sciencebasedmedicine.org/high-dose-vitamin-c-and...
He died in 1994, of cancer.
Re: Vitamin C kills tumor cells with hard-to-treat mutation in mice
#3Kind of depressing that the study to investigate vitamin c injections won't get funded because drug companies can't sell it.
Re: Vitamin C kills tumor cells with hard-to-treat mutation in mice
#4On a side note, Linus Pauling was notorious for, late in life, after winning all his Nobels and other such prizes, pushing the idea that megadoses of Vitamin C would cure all cancers: https://en.wikipedia.org/wiki/Linus_Pauling#Medical_research... https://www.sciencebasedmedicine.org/high-dose-vitamin-c-and... He died in 1994, of cancer.
There are really many types of chancer, and Vitamin C (if confirmed) seems to help only from some types of it.
So that he died of cancer say absolutely nothing about Vitamin C.
Re: Vitamin C kills tumor cells with hard-to-treat mutation in mice
#5Kind of depressing that the study to investigate vitamin c injections won't get funded because drug companies can't sell it.
This. Article ends with:
> But Cantley says it may be possible to make an oral formulation that reaches high doses in the blood—which may be one way to get companies interested in sponsoring trials.
Re: Vitamin C kills tumor cells with hard-to-treat mutation in mice
#6On a side note, Linus Pauling was notorious for, late in life, after winning all his Nobels and other such prizes, pushing the idea that megadoses of Vitamin C would cure all cancers: https://en.wikipedia.org/wiki/Linus_Pauling#Medical_research... https://www.sciencebasedmedicine.org/high-dose-vitamin-c-and... He died in 1994, of cancer.
Well, he was 93 years old. That's still kind of beating the odds in a way.
Re: Vitamin C kills tumor cells with hard-to-treat mutation in mice
#7Lots of mice studies don't translate well into humans. This one is highly specific -- a specific mutation. It's unlikely to have much bearing on real world cancer.
Re: Vitamin C kills tumor cells with hard-to-treat mutation in mice
#8Lots of mice studies don't translate well into humans. This one is highly specific -- a specific mutation. It's unlikely to have much bearing on real world cancer.
Very true. To be charitable, the future is in personalized medicine, so if a vitamin C population subset can be well-defined then maybe there's something here. That said, cancer cells are notorious for expressing efflux pumps and in so doing frustrating treatment, and there's every reason to think that would happen here given the high doses and long time needed for therapeutic effect.
I have to say, the very first thing that came to mind when I read the article was Xkcd: http://www.xkcd.com/1217/
Re: Vitamin C kills tumor cells with hard-to-treat mutation in mice
#9Is this why taking Vitamin C is good when you start to get a cold?
Re: Vitamin C kills tumor cells with hard-to-treat mutation in mice
#10Kind of depressing that the study to investigate vitamin c injections won't get funded because drug companies can't sell it.
Well, it won't get funded by a company unless there's a profit incentive, however there's other funding avenues for clinical trials like this. Besides applying for grants (which is extremely slow and extremely time consuming), research institutions often have small amounts of funds for running a trial in house, especially for something like this which only involves a few gene tests and an inexpensive treatment.