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Is Diet-Induced Alzheimer’s Disease Type 3 Diabetes?

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Re: Is Diet-Induced Alzheimer’s Disease Type 3 Diabetes?

#11

Post by einarvollset »

gavazzy wrote: post #8
rhinoceraptor wrote: post #5

Earlier quoted context omitted.

There is evidence of the neuroprotective effects of a ketogenic diet (low carb, moderate protein, very high fat) [1][2]. The original formulation of the ketogenic diet was for epilepsy, after all [3]. The dogma for decades has been that the brain needs glucose to function. A highly simplified and inaccurate explanation of Alzheimer's is that the brain has diminished capacity to use glucose. Luckily, the body has an a…

Blindly encouraging a ketogenic diet can actually be damaging. While the average person slightly benefits from a high-fat, low-carb diet, a small group of people (who have the APOE4 allele) are unable to properly digest fat and thus are greatly harmed by it. Similarly, light alcohol consumption seems to slightly benefit the majority of people. But, for those with APOE4, it causes significant harm. So, tonic for one g…

You seem to have those the exact wrong way around, or? I have never heard any evidence that people with APOE mutations are "greatly harmed" by eating a ketogenic diet. Link? Ditto for alcohol.

Re: Is Diet-Induced Alzheimer’s Disease Type 3 Diabetes?

#12

Post by tptacek »

gavazzy wrote: post #8
rhinoceraptor wrote: post #5

Earlier quoted context omitted.

There is evidence of the neuroprotective effects of a ketogenic diet (low carb, moderate protein, very high fat) [1][2]. The original formulation of the ketogenic diet was for epilepsy, after all [3]. The dogma for decades has been that the brain needs glucose to function. A highly simplified and inaccurate explanation of Alzheimer's is that the brain has diminished capacity to use glucose. Luckily, the body has an a…

Blindly encouraging a ketogenic diet can actually be damaging. While the average person slightly benefits from a high-fat, low-carb diet, a small group of people (who have the APOE4 allele) are unable to properly digest fat and thus are greatly harmed by it. Similarly, light alcohol consumption seems to slightly benefit the majority of people. But, for those with APOE4, it causes significant harm. So, tonic for one g…

Isn't this a little like saying that blindly encouraging the consumption of healthful tree nuts is damaging to people who are allergic to tree nuts?

True, that is, but not at all interesting?

Re: Is Diet-Induced Alzheimer’s Disease Type 3 Diabetes?

#13

Post by rhinoceraptor »

gavazzy wrote: post #8
rhinoceraptor wrote: post #5

Earlier quoted context omitted.

There is evidence of the neuroprotective effects of a ketogenic diet (low carb, moderate protein, very high fat) [1][2]. The original formulation of the ketogenic diet was for epilepsy, after all [3]. The dogma for decades has been that the brain needs glucose to function. A highly simplified and inaccurate explanation of Alzheimer's is that the brain has diminished capacity to use glucose. Luckily, the body has an a…

Blindly encouraging a ketogenic diet can actually be damaging. While the average person slightly benefits from a high-fat, low-carb diet, a small group of people (who have the APOE4 allele) are unable to properly digest fat and thus are greatly harmed by it. Similarly, light alcohol consumption seems to slightly benefit the majority of people. But, for those with APOE4, it causes significant harm. So, tonic for one g…

Of course, a ketogenic diet is quite the shock to the system for the average sugar burner. If you're otherwise healthy, it's usually not a big deal. But if you're using insulin for T2D, blood thinners, etc. and it could be pretty dangerous.

People who are on medications should definitely find a good doctor who knows the full ramifications of a ketogenic diet, and how to taper off medications that treat symptoms reversed by a ketogenic diet.

Re: Is Diet-Induced Alzheimer’s Disease Type 3 Diabetes?

#15

Post by tiatia »

[Linked Page seems to be down]

I once read tha claim that wheat causes Alzheimer's.

The idea that Alzheimer is Type 3 diabetes it not new. I also remember a paper which claimed that nasal applied insulin improves Alzheimer symptoms.

Assuming that Alzheimer could be a type of diabetes and taken into account a connection between Diabetes I and Celiac disease, the idea that Wheat consumption could trigger Alzheimer is not absurd.

Re: Is Diet-Induced Alzheimer’s Disease Type 3 Diabetes?

#16

Post by linkydinkandyou »

We need to start holding people accountable for self-induced disease. Perhaps with taxes: tax the obese.

However, even the people who think that "Alzheimer's" is "Type-3" diabetes don't believe that all senile dementia is "Type 3 Diabetes" or is diet-induced. Just certain types of it.

But being obese is so unhealthy, and so easy to control (just eat LESS) that to not hold people accountable for it is not good or just.

Re: Is Diet-Induced Alzheimer’s Disease Type 3 Diabetes?

#17

Post by gavazzy »

einarvollset wrote: post #11
gavazzy wrote: post #8

Earlier quoted context omitted.

Blindly encouraging a ketogenic diet can actually be damaging. While the average person slightly benefits from a high-fat, low-carb diet, a small group of people (who have the APOE4 allele) are unable to properly digest fat and thus are greatly harmed by it. Similarly, light alcohol consumption seems to slightly benefit the majority of people. But, for those with APOE4, it causes significant harm. So, tonic for one g…

You seem to have those the exact wrong way around, or? I have never heard any evidence that people with APOE mutations are "greatly harmed" by eating a ketogenic diet. Link? Ditto for alcohol.

My original post is correct. APOE 4/4 is sensitive to dietary fat; high fat diets cause large LDL [0]. Further, fat causes atherosclerosis in APOE 4/4 individuals more quickly than others [1].

It would make sense that APOE 4/4 would have this effect, because it is the "defective" form of APOE. Individuals with APOE 4/4 do not clear oxidized fats from the brain as quickly as APOE 2 or 3 individuals.

[0] http://jn.nutrition.org/content/134/10/2517.full [1] http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2674716/

Re: Is Diet-Induced Alzheimer’s Disease Type 3 Diabetes?

#18

Post by gavazzy »

tptacek wrote: post #12
gavazzy wrote: post #8

Earlier quoted context omitted.

Blindly encouraging a ketogenic diet can actually be damaging. While the average person slightly benefits from a high-fat, low-carb diet, a small group of people (who have the APOE4 allele) are unable to properly digest fat and thus are greatly harmed by it. Similarly, light alcohol consumption seems to slightly benefit the majority of people. But, for those with APOE4, it causes significant harm. So, tonic for one g…

Isn't this a little like saying that blindly encouraging the consumption of healthful tree nuts is damaging to people who are allergic to tree nuts? True, that is, but not at all interesting?

The effects of tree nut allergies are acute and visible, but the effects of APOE genotype are chronic and insidious. Further, genetic testing is readily available and cheap ($99), so that the cost of determining whether someone should have a low-fat or high-fat diet is far outweighed by the benefits of:

a) lowered risk of alzheimer's b) lowered risk of calcified deposits c) lowered risk of stroke

Re: Is Diet-Induced Alzheimer’s Disease Type 3 Diabetes?

#19

Post by gavazzy »

mrfusion wrote: post #10
gavazzy wrote: post #8

Earlier quoted context omitted.

Blindly encouraging a ketogenic diet can actually be damaging. While the average person slightly benefits from a high-fat, low-carb diet, a small group of people (who have the APOE4 allele) are unable to properly digest fat and thus are greatly harmed by it. Similarly, light alcohol consumption seems to slightly benefit the majority of people. But, for those with APOE4, it causes significant harm. So, tonic for one g…

So you think apoe4's should eat a high carb diet?

Not necessarily high in sugar, since the insulin causes just as much damage as high fat. But a lower-fat diet would be beneficial

Re: Is Diet-Induced Alzheimer’s Disease Type 3 Diabetes?

#20

Post by atomical »

fallous wrote: post #3

I'm willing to consider that Alzheimer's Disease may be affected by diet, but this article seems awfully slim on real data and in one instance seems to diverge from actual experimental results. They claim that Type-2 diabetes and AD are "exacerbated by high fat diets", but the link with regards to the diabetes study specifies diet-induced obesity, not "high fat" diet. Dietary fat has much less effect on blood glucose…

A steak causes the release of as much insulin as pure sugar.

Also, http://nutritionfacts.org/video/lipotoxicity-how-saturated-f...

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