Earlier quoted context omitted.
I can't think of anything more standard than /usr/local/.
It's been a while since I looked into it, but I opted to stick with MacPorts rather than Homebrew in large part because I got the impression that Homebrew wanted to own /usr/local rather than sharing it with other software. (Maybe that's inaccurate?) I still occasionally compile software by hand rather than through a package manager, and /usr/local has been the default target for a system-wide install on every Unix-s…
[1] https://github.com/Homebrew/homebrew/blob/master/share/doc/h...