I take SSRIs (Lexapro). I find them helpful. But I think they may be safer in a mature, experienced, rational person which, unfortunately, doesn't reflect the reality of a lot of depressed people. I understand what the drug does and react and modify my behavior accordingly.
Analysis of Antidepressant Paxil Finds Data on Teen Risk Was Held Back
61–70 of 93 posts
Re: Analysis of Antidepressant Paxil Finds Data on Teen Risk Was Held Back
#62Earlier quoted context omitted.
marincounty just uses a lot of question marks. Your nasty attack is incorrect, and you should probably apologise.
I'm sorry, but one can't "just use a lot of question marks" without completely destroying whatever meaning they're trying to get across. I don't give a rat's ass if someone confuses "their" with "there", or "it's" with "its". The meaning is entirely left intact. But ending every single sentence with a question mark is very confusing to the reader. I still have no idea if marincounty is agreeing with the parent, calli…
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Re: Analysis of Antidepressant Paxil Finds Data on Teen Risk Was Held Back
#63Earlier quoted context omitted.
marincounty just uses a lot of question marks. Your nasty attack is incorrect, and you should probably apologise.
I'm sorry, but one can't "just use a lot of question marks" without completely destroying whatever meaning they're trying to get across. I don't give a rat's ass if someone confuses "their" with "there", or "it's" with "its". The meaning is entirely left intact. But ending every single sentence with a question mark is very confusing to the reader. I still have no idea if marincounty is agreeing with the parent, calli…
Confusing it's and its is a minor grammatical error. Generally, making this mistake does nothing to change an expression's meaning.
Responding to criticism by inventing hyperbolic scenarios and punctuating them with questions marks is not a minor grammatical error. It is a rhetorical technique that usually, if not always, signals bad faith.
marincounty may not be a troll, but he sure writes like one. If he wants to be taken more seriously, he'd be well advised to find a style of engagement that hasn't become synonymous with dubious intent.
Re: Analysis of Antidepressant Paxil Finds Data on Teen Risk Was Held Back
#64Why are you ending every sentence with a question mark? It makes you sound unsure?
We detached this subthread from https://news.ycombinator.com/item?id=10239014 and marked it off topic.
Re: Analysis of Antidepressant Paxil Finds Data on Teen Risk Was Held Back
#65This is an egregious violation on many levels. It highlights a massive gap in the clinical trials process (companies can stop trials without reporting negative results) that really should be addressed. I think everyone (outside of drug companies) can agree on that much. I would like to say a few words on SSRIs (the class of drugs that Paxil is in) and their risks in general, because articles like these tend to cultiv…
I appreciate the very well-thought-out comment. It seems to be fashionable to dislike SSRIs but I've been on an SSRI for a severe anxiety / panic disorder for around six years. and it's the _only_ thing that ever eliminated panic attacks by 100%.
> Perhaps the biggest problem with SSRI treatment is the delayed onset of action. Unlike short-term rewarding drugs such as stimulants or opioids that may boost one's mood in the short term but quickly develop tolerance, SSRIs work through long-term adaptive changes.
I see this more as a godsend than a problem. Other meds I've taken, such as mirtazapine, work fast but poop out as soon as I develop a tolerance. Citalopram seems to work indefinitely once those adaptive changes take place.
My psychiatrist a few years back took this into account and prescribed both, and it worked brilliantly. As soon as the mirtazapine's effects were wearing off, the citalopram started kicking in.
Re: Analysis of Antidepressant Paxil Finds Data on Teen Risk Was Held Back
#66I use to work in pharma research (at the data acquisition and analysis side, blinded from treatment) and the fact that pharmas are able to start clinical trials and then shut them down without reporting result is a problem. The folks who make those decision usually have access to unblinded data and in the least objectionable case they do it due to lack of efficacy but you never know. Maybe they found a side-effect an…
> pharmas are able to start clinical trials and then shut them down without reporting result is a problem. As you've worked in the industry, I'm curious: What do you think could remedy this situation? Forcing all registered clinical trials to release all of their data seems like the obvious solution. We still need the ability to shut down clinical trials if unexpected side effects such as increased suicide rates appe…
Re: Analysis of Antidepressant Paxil Finds Data on Teen Risk Was Held Back
#67Earlier quoted context omitted.
> pharmas are able to start clinical trials and then shut them down without reporting result is a problem. As you've worked in the industry, I'm curious: What do you think could remedy this situation? Forcing all registered clinical trials to release all of their data seems like the obvious solution. We still need the ability to shut down clinical trials if unexpected side effects such as increased suicide rates appe…
One option: https://en.wikipedia.org/wiki/Contract_research_organization
How is that a solution? I worked for a CRO and contractually, all we did belonged to the client, including all publishing rights on all results.
Re: Analysis of Antidepressant Paxil Finds Data on Teen Risk Was Held Back
#68I use to work in pharma research (at the data acquisition and analysis side, blinded from treatment) and the fact that pharmas are able to start clinical trials and then shut them down without reporting result is a problem. The folks who make those decision usually have access to unblinded data and in the least objectionable case they do it due to lack of efficacy but you never know. Maybe they found a side-effect an…
> pharmas are able to start clinical trials and then shut them down without reporting result is a problem. As you've worked in the industry, I'm curious: What do you think could remedy this situation? Forcing all registered clinical trials to release all of their data seems like the obvious solution. We still need the ability to shut down clinical trials if unexpected side effects such as increased suicide rates appe…
Mandatory release is useful. At least Phase 3 and 4 trials conclusions should probably require publication. Phase 2 is less essential, drug will never go for sale without a Phase 3. Just saying "nope, won't continue with drug" in a press release doesn't really explain why.
However, I think Phase 2 trials for new use of already approved compound should have a minimum publication requirement if they don't follow on to a phase 3. The safety (side effects and adverse events) should at least get aired.
Re: Analysis of Antidepressant Paxil Finds Data on Teen Risk Was Held Back
#69Earlier quoted context omitted.
>> When I say they, I don't mean the faceless corporation or brand, but the individuals who made this decision... Hopefully they're scared shitless right now because of the talk around the GM recall case. Politicians are throwing around the idea of criminal charges because they didn't disclose safety problems soon enough. My first thought was "what about pharma?" Not sure what I think of the idea, but some folks in p…
Medical problems are difficult to class action because they are so distributed and so private. Earlier this year a doctor killed a family member of mine by telling her, across multiple visits in the same week, her swollen ankle was a sprain and to just rest. It was actually a blood clot due to being overweight and on birth control pills. The day after her last visit, she threw a PE and died alone on her couch. Anothe…
That's unfortunate and sad. But we were talking about researchers and bureaucrats with data, whose job is making data driven decisions, and then ignoring or hiding some of the data.
Re: Analysis of Antidepressant Paxil Finds Data on Teen Risk Was Held Back
#70I've been seeing this pop up on all the major news outlets and science websites, but still have not seen one mention of the side effect that may be behind both increased risk of suicide and increased risk of violent behavior: akathisia. Akathisia is a side effect of antidepressants that causes an intense inner restlessness and inability to sit still. This can cause agonizing pain and terrible anxiety, and people can…
What concerns me as much as the initial side effects is your last paragraph, and the sentiment surrounding it. Benzos have been known to have some additional significant neurological consequences in the long term, and have always felt to me like a rather large sledgehammer for the problems they often treat. As such, "your behavior-modifying drugs give you a side effect so we'll shove more powerful drugs in your face"…
> As such, "your behavior-modifying drugs give you a side effect so we'll shove more powerful drugs in your face" was an attitude that I've seen multiple times and NEVER to good effect.
I don't see why that couldn't make perfect sense, though: someone can be neurochemically imbalanced along multiple axes, but one imbalance can mask the other. For example, if I have ADHD (for real) and depression, then that'll look like I just have depression. If I'm not getting out of bed, you're not going to observe me being very impulsive or notice when I fail to desire to practice things.
But now, if I take an anti-depressant and the depression goes away enough for me to get out of bed, it looks to the study like "in some people, a side-effect of treatment X for depression is [the symptoms of ADHD]." What it really was is that I had a comorbidity.