I'll cover initial impression first, and then go from there into specific things I notice.
First impression: way too much pimping, way too little describing. The front page seems more focussed on who uses it and how awesome they think it is than on what it is. I have a vague idea from your bulleted list, but no idea what differentiates this from all the other CRM systems. The companies you list might, but that is of no use to me. I'm not about to waste my time and contact them to tell me what you should have told me. The video might tell me, but I'm not compelled to watch the video. That combined with the odd and elongated layout would have the average customer uninterested in learning any more about the product.
Specific things:
* Please, please remove the scrolling images part of the way down. They are distracting and get annoying after more than a few seconds.
* Your page goes on below the fold on a 1024x768 monitor, and you have marketing content below that fold. This is very bad. I would honestly take the box of specific features and shove that near the top. In fact, that and a 2-3 sentence description of what the product does is all I could imagine being necessary on the front page. The client list and press hits could either sit at the bottom, or go on another page.
* The page flow is very odd. I'm having a hard time figuring out where my eyes ought to be going. There is that weird block of white space right below the press icons, and on either side of that irritated scrolling thing, which make it hard for me to keep track of where I am on the page. I get the sense that you could solve the page flow problem the need for scrolling at the same time, just by taking advantage of the space you haven't used yet.
I should add the disclaimer that I am not a professional designer, and so some of the things that bother me might be considered good practice by people in the know.
Hope this helps.