Earlier quoted context omitted.
Have you used Tweetbot? I find it to be an incredible desktop (and mobile) twitter client. Even syncs your scroll position between the two.
No, I haven't. Probably the sort of thing Twitter should have in their own stable though. They should have better app options for content creators IMO. Not every user in a news-dominated social network is going to be a passive reader.
It has kind of happened already — Twitter bought Tweetie, which was a well-liked desktop client, and then let it languish.