Viewing profile — sam537

I have completely lost track of what I have read and my thoughts. I really should journal. That being said as somebody else mentioned this is very pleasing to the eye. The UI with …

I came to say this. Free episode to listen to. If you are interested in this it is Nx more cost-effective to listen to Liemandt than to read the adjective laden article.

Popular and incompletely understood. That analogy is unhelpful to understand processes. It's attempting to explain a incompletely understood phenomenon with another. As someone els…

You should check out a currently approved drug that is very similar called amivantamab (Rybrevant). Also targets EGFR and MET (MET can sometimes be a resistance mechanism to EGFR b…

The problem here is the potential toxicity of this combination. In lung cancer for example, the combination of anti-EGFR therapy + pembrolizumab led to deadly pneumonitis (lung inf…

Maybe I can help. Progression is usually defined by radiological endpoints (RECIST 1.1 criteria) meaning that at timepoint x the tumor stayed the same size, got smaller, or grew le…

I am close to some of these institutions and it pains me to hear the trouble you had just getting an answer a yes or no answer or getting your paperwork checked for eligibility. In…

Some comments about dietary science are true. It is extremely impossible to isolate the effect of a single substance (ethically). This person greatly benefited from stopping caffei…

The text was ok, I do not know anything about spermatogenesis but a fair bit about the JAK/STAT pathway. The abstract was pure LLM, however. It has been retracted.

Not only that. The JAK "pathway" is complete gibberish. The third figure is a pool of random spheres in "differentiation" steps. The whole Frontiers publishing group is widely seen…

As an animal with similar fastidiousness, I agree. I am happy to have found this. Reminded me of After Dark by Murakami.

You should also try immunotherapy (pembrolizumab) with chemo if your CPS is >1% before experimental early phase trials.

Mildly interesting.

The lowest of the low? Based on consonant pronunciation? How can you extract a value judgment from how someone speaks?

This is the bottleneck for one company. We have many companies this size doing the same thing. The issue is large companies (novartis/BMS) sometimes sit on compounds and refuse to …

There are a few vaccines that try to 'make' your immune system recognize an abnormal (read cancerous) protein as foreign (Sipleucel T for prostate, GMCSF vaccine for melanoma). Min…

Look at GRAIL therapeutics. Cancer sheds DNA that can be detected and amplified. We use this sometimes to try to tell if someone will have a recurrence before scans actually show i…

Oncologist here. You can think of drug development as an extremely wide funnel with a minuscule exit hole. At any given time a medium sized pharmaceutical company has 300-500 drug …

The internet can still be a beautiful place.

I wonder how many of us got sidetracked into playing at work today.

There are two types PD1 and PDL1 inhibitors. Cancer cells (and our own cells) express PDL1. Our immune cells touch PDL1 with their PD1 and if this connection works then the immune …

This is misleading. Yes, the response rate is extremely high but all of this patients shared a mutation or a group of mutations in mismatch repair proteins (they were all MMR defic…

Thank you.

It's great to talk in terms of indices and devaluations and of "breaking the bank of England". The lives affected are not even spared an afterthought.