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phreeza

HN member
Joined
Fri, May 21, 2010, 4:23 PM UTC
HN karma
9,352
Public activity
2,132 items

About phreeza

my email is thomas.mccolgan at g[oogle]mail dot com

i intermittently blog at phonons.wordpress.com

Working on making better proteins with machine learning at cradle.bio

[ my public key: https://keybase.io/tmco; my proof: https://keybase.io/tmco/sigs/P9gtvzmXYJ6NlWm18exm-PIA-JC6RWYr0qUDqxgitSs ]

Recent public activity

  1. comment
    Comment #49174891

    Funny there the date is April 1985, a lot earlier and almost my birthday!

  2. comment
    Comment #49018769

    I think a lot of LLM progress in the last 2 years or so is really from densifying the training data to niches like this and not so much from general problem solving capability. I g…

  3. comment
    Comment #48981660

    This is a pretty stunning result. The time series looks really convincing. Is the way the detector itself is trained orthogonal to this or could there be some "leakage" in that the…

  4. comment
  5. story
  6. comment
    Comment #48893824

    For Switzerland, that's only true for the special tourist train panoramic carriages on the route, there are normal trains running on the same routes, too, that don't require reserv…

  7. comment
    Comment #48793609

    Or solar geoengineering? Which is scary but becoming more likely it seems.

  8. comment
    Comment #48757337

    I think this is a complete misunderstanding of what people mean by taste in software engineering. Taste is more like the System 1 response one builds to code over time, which (idea…

  9. comment
    Comment #48612585

    Was just going to ask if anyone remembered the name of this one. It was amazing! 15 year old me felt very important/futuristic syncing the news before school in the morning and rea…

  10. comment
    Comment #48525309

    Maybe its more like the hash was a well known secure hash but someone managed to extract the salt/private key/signing certificate from the camera?

  11. comment
    Comment #48422141

    I ran Claude Code on my ca 2015 ThinkPad which was having wifi issues and asked it to fix them. It diagnosed the problem and applied some obscure kernel flag which fixed the issue.…

  12. comment
    Comment #48394784

    There are plenty of expenses in this order of magnitude that are not tied to direct increases in productivity. I think it may become a serious hiring impediment for companies to be…

  13. comment
    Comment #48385251

    Is it really that different with the current iteration of AI compared to what was possible 10 years ago? There may be some new awareness at the executive level of what is possible,…

  14. comment
    Comment #48361710

    Pretty sure op is talking about university in Spain for other subjects, not Spanish class at university.

  15. comment
    Comment #48274928

    I think it's just a joke/reference to HAL in 2001: A Space Odyssey

  16. comment
    Comment #48125487

    The most amazing thing to me about Cider-V was that Cider (without the V) actually went away after a relatively short amount of time, when virtually every other internal service th…

  17. comment
    Comment #48125342

    A rare breed!

  18. comment
    Comment #48123955

    That seems possible for generating completely new proteins. Do you think it's also the case for lead optimization where you typically have some degree of measurements around your s…

  19. comment
    Comment #48072162

    Check out manifold markets, sounds like that is what you are looking for?

  20. comment
    Comment #47950279

    Would you be open to sharing a version of your pitch deck? The main question in my mind is what kind of exit the VCs have in mind when they give you this money.

  21. comment
    Comment #47868534

    It seems like college towns have a lot of players even if they are small, what's the reason for that?

  22. comment
    Comment #47817705

    That's definitely true for some of them, but for others it's not so clear, like the Apollo or Manhattan projects? Those of course also have lasting impact but it's more in terms of…

  23. comment
    Comment #47798055

    What do you mean you heard? Are you not a member of their team? Your posts in the last hour seem quite astroturf-y.

  24. comment
    Comment #47572568

    Numerical issues totally exist but the reason has nothing to do with the fact that Cauchy sequences don't exist on a computer imo.

  25. comment
    Comment #47572148

    I understand that much, but it seems like "your naive timestep may need to be smaller than you think or you need to do some extra work" rather than the more fundamental objection f…