Viewing profile — jdietrich

>There are many, many psychedelics. They have sometimes radical differences. Psilocybin is a more selective 5-HT2A agonist than LSD and is more rapidly metabolised. At normal recre…

The question posed is "Could psilocybin be the key to treating anorexia?". Psychedelics are effective in treating some psychiatric disorders - I've been clear about that - but they…

Sorry, but the answer is almost certainly no. We now have good quality data on psylocybin as a treatment for depression; at best, it's slightly more effective than existing treatme…

Living standards for ordinary people only started to improve in any meaningful way after the industrial revolution, a fact which is immediately obvious if you compare across genera…

Nigel Farage is the incumbent Member of Parliament for Clacton and the de-facto leader of Reform UK, a populist right-wing party that has only a handful of MPs but is currently lea…

Has any group of workers ever "won" a long-term victory against a new technology? There are plenty of short-term concessions made in the face of powerful trade union opposition, bu…

Ergonomics. Any solid-body guitar that's designed to be comfortable when played sitting or standing will converge on a strat-ish body shape. You can make a computer mouse in any sh…

Precisely this. Ticketmaster's entire business model is based around taking the blame. Artists don't want to set a face value for their tickets that represent a realistic market-cl…

As a Brit, it seems hilarious that a single person with an income of $97k would be on the poverty line. That's more than double the median income for all households in the UK. A lo…

>battery powered grinders that will cut any lock Not any more. A new generation of locks have an abrasive-filled plastic layer that aggressively wears down angle grinder discs. The…

>Adhesives are a deep and interesting subject. It's notable that adhesives are something that Chinese manufacturers still really struggle with. Companies like Henkel and 3M have a …

The electrical telegraph was integral to the growth and consolidation of the British Empire. Britain acquired more colonies and held on to them for longer than the other European p…

If I had a dollar for every device that I've seen ruined by leaking alkaline cells, I could buy a palletload of lithium cells.

Lithium primary cells have a shallower discharge curve than alkaline, but not completely flat; measuring state-of-charge is essentially trivial for any competent design engineer. M…

Eneloop Pro cells have a rated capacity of 2500mAh. I can't think of any good applications for conventional NiMH cells any more - they're dominated by LSD NiMH cells in low-dischar…

Unless you're doing something blatantly wrong or have a very specific disorder like coeliac, diet just doesn't have very much influence on health. There are a very wide range of di…

Most things in the Chinese military system are numbered rather than named. Military units are numbered twice - a public cover designator and a private true unit designator, origina…

Ask any EMT or paramedic - an astonishingly large proportion of human drivers panic in the presence of an ambulance and just slam their brakes on.

How valuable are those trophies compared to bribes, or the tacit bribes of cushy "consultancy" roles? How do you stop lobbyists from gutting those regulators - what use is a fierce…

Unit 8200 hand-picks the best and brightest young Israelis and trains them in computer science. You might as well say "It's always MIT" - of course an elite educational institution…

It's more to do with the bureaucratic costs of getting a product licensed as a medical device. By the standards of the medical industry, an F1 wheel nut gun or a WEC refuelling rig…

To reiterate a crucial point in this comment, replacing the Office apps is the least of the issues. Enterpise customers rely on 365 for identity management, endpoint protection, bu…

Users have "brutally rejected" pretty much everything that Microsoft have done since MS-DOS. Some cohort of users will get incredibly angry about any conceivable change to mature s…

>Like lobotomies. What do people think of them now? Lobotomy was in fact an effective treatment (albeit with extremely severe side-effects), but we now have much better and safer t…