Viewing profile — glp1guide

I keep track of GLP1s and write a lot about them (looking for negative side effects, research results, etc) and it is amazing how potent retatrutide is. It’s not simply a matter of…

> I'd love to see more research around this. Looks like we posted around the same time, but see: https://news.ycombinator.com/item?id=46945756

No one knows of course, but it's looking likely -- anecdotal data is piling up. That said, there are some that have reported it also lessens desire for things they want to desire. …

Just stating the obvious -- losing weight (and likely lowering HbA1c/having other benefits) for 18 months is probably infinitely better than never losing weight at all.

> Of the 308 who benefited from tirzepatide, 254 (82 percent) regained at least 25 percent of the weight they had lost on the drug by week 88. Further, 177 (57 percent) regained at…

Like others have mentioned, liraglutide already exists as a generic! It's not as good as Semaglutide or Tirzepatide, but. Also, a lot of people are still getting compounded GLP1, t…

At this point most experts lean more heavily on the effect of GLP1s in the brain rather than delayed gastric emptying -- it's more of a brain drug than anything else which is why i…

Basically, the gastro-intestinal side effects are the biggest issue, along with CVS (not the store) and possibly eye problems. That said, the negative side effects look to be incre…

A bit late, but thanks for noting this -- I had no idea that this workaround was so well established. I don't often dive into concrete suggestions on how to obtain GLP1s because of…

Absolutely -- certainly in their biggest markets they'll be able to protect those patents. Both companies have thus far been unable to really stop compounding pharmacies and/or gra…

Not only that, there is a legitimate raft of companies lining up to make generics. There’s one wrinkle though, legally importing prescription drugs from Canada isn’t really allowed…

Yeah weirdly enough they’re only taking NAION and gastroparesis cases. Do you know by any chance why that is? The NAION link is tenuous (research was inconclusive, I have written a…

That sounds like a terrible experience, sorry you and the wife went through that and somehow the negative side effects STILL persist. This is honestly the first case I’ve ever hear…

Do yourself a favor, and just take GLP1s instead (after talking to your health care professional). The research on the effects is plentiful, they're incredibly effective, and next …

Sorry a bit late here, but the numbers for CagriSema are actually not as good as Retatrutide's were. Unless I'm missing something: Reta 8mg -22% body weight at 48 weeks CagriSema -…

This is a valid concern but the subreddits I'm thinking about are not quite that -- no one is selling or trying to push you to some distributor, it's a lot of the bodybuilding/pept…

Interesting -- would love to hear anything more you have to share! The research numbers would suggest that Reta was top, results wise. Any other significant differences you felt/no…

Well for one they're flying in the face of the patent protection in place for Retatrutide -- that said the legalities around distributing prescription drugs or unknown chemical sub…

Well there's no reason, except it's even more effective. And 100%, using Retatrutide right now is illegal/not a good idea. It is super risky. That said, anecdata from people with t…

> If Eli Lily is the only producer, how is the gray market being supplied? This makes no sense... It turns out enterprising chemists and pharmacists are capable of reverse engineer…

It's completely illegal -- the drug is not for sale, obviously is not FDA approved, and is not manufactured anywhere, the only safe/legal way to get it is a via an ongoing trial: h…

I'm incredibly interested -- it's just not legal yet, and the drug is in trials by Eli Lilly: https://trials.lilly.com/en-US/trial/580035 Just to be very explicit here, my profit i…

If you think Ozempic (Semaglutide) is good, Retatrutide is going to blow it out of the water: https://glp1.guide/content/a-new-glp1-retatrutide/ Currently the only people experimen…

Nope, because the change is actually in the brain . https://glp1.guide/content/research-on-glp1-signaling-in-the... https://glp1.guide/content/research-suggesting-glp1-is-a-bra... …