Viewing profile — fgimenez

[Note that I work in this field and have co-founded a CNS AAV company] This isn't the correct takeaway. AAV are one of the most complex drug modalities and carry considerable risk …

They have a lot of anecdotal, observational, and emerging RCT evidence on their effects on substance consumption and abuse. The biggest effect and best tested is on alcohol use dis…

Basic research creates foundation knowledge that can drive medical innovation, but rarely does academic research create final composition of matter. Private funded work is all the …

First-gen GLP-1 goes off patent in 2031 (e.g. semaglutide). Seems far off, but is frighteningly close for Novo. Tirzepatide gets genericized in 2039 and has better efficacy, which …

Yes absolutely. Even if you have already been exposed, the vaccine has been shown to prevent manifestations and/or recurrence of HPV-induced pathologies. It's not necessarily in st…

My pithy observation - Early stage investors are fantastic at extrapolating from minimal data points. Late stage investors are fantastic at extrapolating from many noisy data point…

> I wouldn’t be surprised if companies threw billions of dollars worth of research to make it happen Well you are correct. Altos labs ( https://altoslabs.com/ ) is basically every …

Go through a staffing agency. They will manage background checks and can introduce you to many people across a variety of skill sets.

I am VC. I invest in hard tech. That said, opinions are my own. Unless you come in with a strong background reputation or intro from the top 1% of our network, I would probably not…

I cannot comment on a full macro basis, but it is definitely true that being listed on an index such as S&P 500 will spike the market cap. TSLA was a recent example here. Matt Levi…

I chatted with an affiliate of the counterparty to the bet here - a couple years before the bet ended but clearly when they were gonna lose. They did say two interesting things I'l…

My experience has been to say "yes" to everything in early career when you are not in demand. Then slowly transition to saying "no" as your career develops. The transition point fr…

This is such a cool idea. The gap between the "aha" moment of a programming challenge and the implementation is high for me since I don't get to code very much anymore. Can't wait …

Really depends on the type of cold email. If an investment banker cold emails me with a “hot deal” I delete immediately. If a founder sends me a template email in a space I clearly…

I’m a VC, so this take is biased. Liberally apply grains of salt. If you are looking to start a VC-scale startup, I’d suggest talking to VCs who can help introduce you to domain ex…

I have met one person who did it. Even then they were a certifiable genius, still had to jump through an enormous amount of bureaucracy with an enormous amount of sponsorship from …

- Norvig's AI: Doesn't have much deep learning, but you get through it and understand the expansiveness of the field. - Algorithms - Papadimitrou and Vazirani: I had a professor wh…

They are a phenomenally cool drug delivery vehicle as you can get differential uptake based on their surface markers. Check this out: https://www.sciencedirect.com/science/article/…

Yes, you could frame the Voyager treatment as "better levodopa". Though, the mechanism would feasibly mitigate neuro-degeneration and improve the terrible dose escalation of the dr…

I sincerely think we are in the gene therapy renaissance. Delivery has always been an issue, but there are new tricks coming out with regard to cell-specific targeting. We can pigg…

Most biotechs don't have any revenue when they go public. They are traded on scientific progress through clinical trials. The idea being that if they do get through a phase 3, they…

Incredible. Also, getting treated by Steve Rosenberg is so awesome. Your results are literally the reason he'll get the Nobel prize within 10 years.

While robots are a stretch, there are a ton of companies taking blood samples and sequencing DNA floating around. Karius does exactly what you mentioned by sequencing and searching…

I fund people like this a lot. They're always hiring developers for the bioinformatics parts of their products