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Yes, but I would say quality is most important in almost all cases. Well, quality being defined as The most compelling near term applications (NITP etc) use fragmented DNA, and lon…

Do you have a citation for this? Because this is not my understanding.

Most clinical applications don’t need long reads. Pathogen identification from short reads is easy. Blood tests for cancer, and NIPT (which will likely be the first big application…

They’re going to need more money. I think they’d need to sell >10,000 units a month. That is if they are making any kind of profit. Unfortunately I don’t think there’s a market for…

I think they like to say they have a patent monopoly, but I don’t believe they do. Genia (which also has issues) are developing a protein nanopore platform. Illumina (see recent IP…

I would guess they currently make a loss on every device shipped. Most current sales are about generating press coverage/traction, not revenue.

The accounts of all UK companies are filed publicly. They had about 1M GBP of sales in 2016 from memory. I would guess with overheads, each unit is currently sold at a loss. Illumi…

That might be the case if the throughput wasn’t so low and the error rate wasn’t so high.

I’d agree with you, that long reads would be useful if the error rate wasn’t so shockingly bad. There is, likely value in long reads, but what non-niche research applications are t…

NextSeq is expensive, but there are cheaper options (from 30k) and you can just send your samples to a sequencing service. I’ve seen costs for a whole human genome at high coverage…

That’s great, but for a company that has raised on a valuation of >2BUSD how are they going to compete with Illumina. The read lengths might be long, but the error rate is a couple…

It’s also comparatively expensive compared to other platforms (you can get a full human genome sequenced at high coverage for between 1000 and 3000 USD). The error rate is stupidly…

Work for a year then take two years off? Or retire earlier? Again, I didn’t say that people wouldn’t work at all. I said that the barrier to obtaining a personal autonomy is too hi…

Can be useful when you’re looking after kids, you’re carrying a child/stuck away from your phone. I’d guess voice assistance could be useful in other situations too. But for me the…

I’m not really talking about providing a basic income. What I’m saying is the barrier to having “personal autonomy” in a society where providing the essentials of life has to a hig…

The last sentence really stuck home to me (edited for clarity): While these Red Ocean ideas may not result in creating multibillion dollar companies they do offer opportunity that …

Only if you have multiple devices... it would be nice if they supported this optionally (it would be nice if they supported any kind of end-to-end backup optionally).

It’s an AI using deep learning and therefore magic requiring no explanation.

I think they want to support the scenario of lost device, lost password, but still allow restoring data to a new device.

Yes, they obviously have the infrastructure to do it. However, they don’t even optionally. Part of the reason is that people sometimes forget their passwords and that would lock th…

I probably could have been more tactful. However the substance of my comment is correct, and while I believe Apple do great things in security and promoting privacy rights, they do…

Would you care to link to the section of the security white paper that says that? There’s a small subset of data that is encrypted end-to-end. Your photos, notes, most and most oth…

If I’m going to be downvotes, could someone at least link to a document that shows how these statements are incorrect?

The statements only refer to: “When files are created in Data Protection classes that aren’t accessible when the device is locked” So not photos, most data.

This contradicts statements made by Apple, most information in iCloud backups is not encrypted end-to-end. https://support.apple.com/en-us/HT202303