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There have been efforts to standardize antibody reagent testing that are sorely underfunded/undervalued, https://ycharos.com/ ( https://www.nature.com/articles/s41596-024-01095-8 )…

Github issues will be the real social network for AI agents, no humans allowed!

Author made it clear this was an educational essay, but concluding the problem has very limited therapeutic applications comes across like a bit of a take down for Atomic AI's plat…

Heck yes. Music pirates have done a whole lot to help preserve hip-hop history by ripping/archiving countless rare/underground 12" and cassettes that are definitely not available o…

This has been a previous area of research for Google ( https://ai.googleblog.com/2017/04/predicting-properties-of-m... ). It remains routine to benchmark GNNs and other molecular m…

I agree with the sentiment of this paper (AF can enable drug discovery), but in this specific instance, the authors had a real opportunity contribute a general finding to the scien…

Not saying it's easy but ribosomal synthesis of consecutive non-canonical amino acids has been achieved by some groups ( https://www.cell.com/cell-chemical-biology/fulltext/S2451-9…

Our startup routinely orders the synthesis of hundreds of peptides for technology validation and drug discovery research (not suitable for human consumption). Costs for a small qua…

There is innovation in this space. From green chemistry initiatives to replace hazardous solvents by CROs/industry invested in large-scale production of peptides, https://www.bache…

One of the reasons we don't have them all is that individual genes can encode for multiple protein isoforms through alternative splicing. AlphaFold was only run on one. Otherwise, …

Just in case you're not joking, it's worth noting that the majority of distributed molecular simulation (past and present) is spent studying "folded proteins" to discover structure…

Everything between the BRCT and RING domains of BRCA1 is an intrinsically unstructured region which DeepMind correctly predicts, https://pubmed.ncbi.nlm.nih.gov/15571721/ Another f…

Yet, there were still 136 human teams who competed in CASP14 ( https://predictioncenter.org/casp14/docs.cgi?view=groupsbyna... ), including DeepMind. Even if a significant fraction…

The process is described in Supplementary, but where do you see the code to train the model? The repository is the inference pipeline.

There's quite a nice plot from a review paper of D.E. Shaw Research that lists the timescale of several biological processes (and compares it to other experimental methods), https:…

So what you're saying is: https://xkcd.com/1831/ , except that CS/ML practitioners have a negative impact by trying to contribute without understanding the nuance. I think the next…

Best of luck. Although not in the majority, there have been many academic recruiting posts on HN in the past.

I know that docking using GPU is about an order of magnitude faster than CPU (see today's Schrodinger 2019-1 release notes, https://youtu.be/K4AYdBvuOe4?t=90 ). Is there a way of d…

The majority of ongoing Folding@Home tasks are not aimed at structure determination, but rather simulating the conformational dynamics of folded proteins (exploring the energy land…

The path is most likely through reliable structure prediction of drug targets. That would open up rational drug design projects that may have previously been impossible. The only p…

This reminded me of a nice article about how blindness evolved in the Mexican cavefish, http://seedmagazine.com/content/article/pz_myers_on_how_the_...

I'm a cofounder of a start-up working on near-term applications of quantum computing in biology, specifically on the protein structure side of things ( https://www.proteinqure.com …

ProteinQure | Machine Learning Engineer, Computational Biologist | On-site, full-time | Toronto, Canada ProteinQure is an early stage deep techy startup building the next generatio…

I'm confused as to why you're addressing this commenter using "argument from authority" when you seem to be weakening your position, suggesting that studying protein dynamics has l…

Relay is not doing protein engineering or working on predicting protein structure. They are making models of protein dynamics to assist in drug discovery (often using already deter…