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Phase 2 clinical trials showed 14.7% mean weight reduction at 36 weeks in adults. That's pretty substantial. Obviously no one knows what Phase 3 will show, but cynicism seems unwar…

We actually have a lot of data on Ozempic and GLP-1s generally, going back to the first GLP-1 FDA approval in 2005: • Exenatide - FDA approved in 2005 • Liraglutide / Saxenda - FDA…

There is a great How I Built This episode about GoodReads: https://www.npr.org/2022/02/04/1078415544/goodreads-otis-and...

Out of curiosity - what are you actually doing on these walks? You're talking outloud to yourself and then editing later or what?

How is copyright / licensing working on this site? Would love to learn!

Bc none of the features are actually live yet. We keep hearing about what will be released and demos - but HN is mainly do-ers. Their launches would have 100x the impact if people …

Will they just be using Microsoft's offices?

If this is happening to you in California - look into California’s Amended Automatic Renewal Law that took effect on July 1, 2022.

SEO - Google ranks those pages higher.

How are you calculating the 2 years of runway? Last I heard they have $1B in cash on hand and are doing roughly $3B/year in revenue. Musk has reportedly gotten their annual expense…

Why do you define United as a cadillac plan? I've only had awful experiences with them thus far.

My guess is that they don’t want to cover a $1,000/month drug to save costs that you may not incur for many years / when you’re no longer insured by them. It only works if all the …

Ozempic is widely available in Mexico (without prescription) and Canada (with prescription). It’s also available throughout Europe. Mounjaro is not widely available outside the US …

100% this. A lot of people on Mounjaro report that one of the benefits is that their internal chatter about food / cravings is silenced. For the first time, when they get hungry th…

We already have it - you can buy Semaglutide easily on the clear net as it’s relatively easy / cheap to manufacture. r/peptides has more info. Disclaimer: I’m not advocating this -…

Same - Mounjaro / Tirzeparide is nothing short of life changing. A question I often get is "how effective is it?" The SURMOUNT-1 study released in April 2022 showed 22.5% average r…

I have a friend who sells Christmas ornaments on Etsy and makes ~$5k every holiday season.

It's partially because we should always act with a degree of caution and skepticism when the government can sentence people to die for betraying the government. With a country like…

They're unlikely to terminate entirely, but they are likely to put a temporary stay on the proceedings which is like hitting the pause button.

Is Warp just a VPN, or is that different?

It's a great thing for the environment, and a bad thing for the economy.

I love Peter Zeihan and recommend him to everyone. His commentary on the intersection of population decline and Russia's geopolitical goals from The Accidental Superpower in 2014 a…

Awesome!