Live data from Hacker News

Metabolic and cellular differences between sedentary and active individuals

howardluksmd.substack.com

1–10 of 159 posts

Re: Metabolic and cellular differences between sedentary and active individuals

#5
post #3

But how do you know if you exercise enough?

+1. I surf occasionally, and go rock climbing a couple times a week. Compared to the "average American" I suspect I'm pretty active. Compared to other rock climbers and surfers, I'm probably relatively inactive. If I'm not concerned about improving at these hobbies, and just want 80% of the health benefit of being active, am I achieving it? Or am I still below?

Edit: From the linked paper:

'''

2.1 Subject Recruitment Nineteen male subjects ((41.9 ± 13.8 years; 82.6 ± 13.9 kg)) participated in this study and were assigned a research arm based upon meeting one of the following criteria related to physical activity:

- Sedentary (SED): n= 10. Does not perform exercise regularly or elevate heart rate outside of daily tasks

- Active (AC): n=10. Performs aerobic exercise for at least 150 minutes per week, and has at least a six-month history of doing so

'''

I bet that "Performs aerobic exercise for at least 150 minutes per week" is related to some standard advice (but I'm too lazy to confirm that. I guess that provides an easy measuring stick to decide if we're being 'active enough'

Re: Metabolic and cellular differences between sedentary and active individuals

#6
post #4

Paper: https://www.biorxiv.org/content/10.1101/2024.08.19.608601v1....

Probably a better link for the post, the current article appears to be an AI generated ad

I do like the scientific paper, but not everyone wants to read a true paper. Can you point out specific deficiencies in the linked article, aside from it being simplified but more accessible?

Re: Metabolic and cellular differences between sedentary and active individuals

#7
post #3

But how do you know if you exercise enough?

+1. I surf occasionally, and go rock climbing a couple times a week. Compared to the "average American" I suspect I'm pretty active. Compared to other rock climbers and surfers, I'm probably relatively inactive. If I'm not concerned about improving at these hobbies, and just want 80% of the health benefit of being active, am I achieving it? Or am I still below? Edit: From the linked paper: ''' 2.1 Subject Recruitment…

[deleted]

Re: Metabolic and cellular differences between sedentary and active individuals

#8
post #3

But how do you know if you exercise enough?

The paper indicated the Active group has doing at least 150 minutes of moderate-intensity physical activity throughout the week, or 75 minutes of high intensity activity activity (matching WHO guidelines[0]), and have done so for at least six months.

Anecdotally, I and several other people have found smart watches good for keeping track of intensity minutes.

[0] https://www.who.int/initiatives/behealthy/physical-activity

Re: Metabolic and cellular differences between sedentary and active individuals

#9
post #3

But how do you know if you exercise enough?

According to the linked paper [0]:

"

- Sedentary (SED): Does not perform exercise regularly or elevate heart rate outside of daily tasks

- Active (AC): Performs aerobic exercise for at least 150 minutes per week, and has at least a six-month history of doing so

"

A more comprehensive study that determines the optimal amount of exercise per week to achieve peak cellular function over a population would be quite interesting. Also, what about anaerobic exercises like weight lifting? What's the relative impact on metabolic function? Lots more to explore here!

[0] https://www.biorxiv.org/content/10.1101/2024.08.19.608601v1....

Re: Metabolic and cellular differences between sedentary and active individuals

#10
Sumo wrestlers generally don't develop metabolic disease until after they retire, which comes with the cessation of their grueling, multi-hour daily training regimens. I wish I could find the NHK report on a group of scientists that were researching how metabolically-undesirable substances build up in muscles after as little as 20 minutes of inactivity.

This is the one thing that makes me so angry about the state of AR/VR/XR. Human bodies are made to move when we work - not strenuously, not non-stop, but consistently and with some amount of vigor. Spatial software design represents an AMAZING opportunity to re-tune digital work processes to be movement-oriented, while still productive and efficient. Compare digital sculpting in ZBrush and Media Molecule's Dreams.

It's maybe harder to envision a similar transformation for people dealing with data or communication for a living, but is it out of the realm of possibility? It shouldn't be, for anyone who who might compare common GUIs to interfaces like VIM and Emacs. The former are the unhappy compromise between the latter and the as-yet-to-be-created spatial interfaces that would be coming if the Bigs would stop trying to outmaneuver each other, and just create them.

I am tired of trying to manage my photo library on a small laptop screen or monitor, with a single pointer. Let me summon them to my physical space and manipulate, stack, sort them, and more, with split controllers or my actual hands. I promise that my brain and body and your wallet will be much, much happier.

Post reply on HN