Live data from Hacker News

Lithium compound can reverse Alzheimer’s in mice: study

hms.harvard.edu

1–10 of 108 posts

Re: Lithium compound can reverse Alzheimer’s in mice: study

#2
Things I love to read.

I went to visit my aunt one day, and my favourite uncle couldn't recognize me. It made me think that Alzheimer's is probably the worst thing that could happen to a person. I mean, what's worse than not being able to recognize those closest to you? You work a lifetime, and then you go out in such an undignified manner.

I pray for a cure in my lifetime.

Re: Lithium compound can reverse Alzheimer’s in mice: study

#4
Lithium orotate is available over the counter. People could try it today.

> Since lithium has not yet been shown to be safe or effective in protecting against neurodegeneration in humans, Yankner emphasizes that people should not take lithium compounds on their own

I reject this kind of blind safetyism. A cursory search suggests that lithium orotate has been used for decades, and the article suggests that "profound effects" were seen at an "exquisitely low dose" which should be safe. They're going to need a much better explanation of why people shouldn't try it.

Re: Lithium compound can reverse Alzheimer’s in mice: study

#6
post #2

Things I love to read. I went to visit my aunt one day, and my favourite uncle couldn't recognize me. It made me think that Alzheimer's is probably the worst thing that could happen to a person. I mean, what's worse than not being able to recognize those closest to you? You work a lifetime, and then you go out in such an undignified manner. I pray for a cure in my lifetime.

It's worse. Not recognizing people close to you is really hard on everyone else(including people taking care of you), but since you don't remember, it's not as bad for you.

You won't even remember whether or not you had lunch. I met a grandma that was distraught that nobody was feeding her and she was hungry. Except she had had lunch already but couldn't remember. You forget where you live so if you get out of the house you can't get back. And many have 'sundowning', they get scared if they are outside and the night falls. It's not just the forgetting either, you start losing fundamental functions and eventually die. Not to mention the aggression and mood swings, which are aggravated if you try to point out that they are forgetting things.

It's a terrible disease. You cease to be you.

Re: Lithium compound can reverse Alzheimer’s in mice: study

#7
post #4

Lithium orotate is available over the counter. People could try it today. > Since lithium has not yet been shown to be safe or effective in protecting against neurodegeneration in humans, Yankner emphasizes that people should not take lithium compounds on their own I reject this kind of blind safetyism. A cursory search suggests that lithium orotate has been used for decades, and the article suggests that "profound e…

People use it in much smaller dosages then it's usually prescribed to apparently beneficial effect.

I believe its also in the water supply in certain places, so if it works for dementia there are natural experiments already running on this.

https://www.psychiatrictimes.com/view/low-dose-lithium-a-new...

Re: Lithium compound can reverse Alzheimer’s in mice: study

#9
post #4

Lithium orotate is available over the counter. People could try it today. > Since lithium has not yet been shown to be safe or effective in protecting against neurodegeneration in humans, Yankner emphasizes that people should not take lithium compounds on their own I reject this kind of blind safetyism. A cursory search suggests that lithium orotate has been used for decades, and the article suggests that "profound e…

> They're going to need a much better explanation of why people shouldn't try it.

Clinical trials need many participants and take a long time, and they require a control group which doesn't take lithium orotate. Finding these people might be hard if everyone is taking it anyway.

Re: Lithium compound can reverse Alzheimer’s in mice: study

#10
post #4

Lithium orotate is available over the counter. People could try it today. > Since lithium has not yet been shown to be safe or effective in protecting against neurodegeneration in humans, Yankner emphasizes that people should not take lithium compounds on their own I reject this kind of blind safetyism. A cursory search suggests that lithium orotate has been used for decades, and the article suggests that "profound e…

> I reject this kind of blind safetyism.

You said you searched to learn more about lithium, but somehow missed that it's highly recommended to be administered by doctors due to side effects after long term use. Anything that damages your kidneys or thyroids can kill you, so calling it "blind safetyism" is silly.

Post reply on HN