Lower risk of dementia with AS01-adjuvanted vaccination

#1

Post by tomsto » Wed, Jun 25, 2025, 5:55 PM UTC

Lower risk of dementia with AS01-adjuvanted vaccination
nature.com

Re: Lower risk of dementia with AS01-adjuvanted vaccination

#2

Post by tomsto » Wed, Jun 25, 2025, 5:55 PM UTC

AS01-adjuvanted shingles (herpes zoster) vaccination is associated with a lower risk of dementia, but the underlying mechanisms are unclear. In propensity-score matched cohort studies with 436,788 individuals, both the AS01-adjuvanted shingles and respiratory syncytial virus (RSV) vaccines, individually or combined, were associated with reduced 18-month risk of dementia. No difference was observed between the two AS01-adjuvanted vaccines, suggesting that the AS01 adjuvant itself plays a direct role in lowering dementia risk.

Re: Lower risk of dementia with AS01-adjuvanted vaccination

#3

Post by fithisux » Wed, Jun 25, 2025, 6:04 PM UTC

tomsto wrote: post #2

AS01-adjuvanted shingles (herpes zoster) vaccination is associated with a lower risk of dementia, but the underlying mechanisms are unclear. In propensity-score matched cohort studies with 436,788 individuals, both the AS01-adjuvanted shingles and respiratory syncytial virus (RSV) vaccines, individually or combined, were associated with reduced 18-month risk of dementia. No difference was observed between the two AS0…

If the underlying mechanism is unclear, we definitely need many more studies to replicate the effect.