Glucagon-Like Peptide-1 Receptor Agonists and Risk of Macular Degeneration

#1

Post by baby-yoda » Wed, Jun 11, 2025, 2:04 PM UTC

Glucagon-Like Peptide-1 Receptor Agonists and Risk of Macular Degeneration
jamanetwork.com

Re: Glucagon-Like Peptide-1 Receptor Agonists and Risk of Macular Degeneration

#2

Post by woliveirajr » Wed, Jun 11, 2025, 2:45 PM UTC

139,000 patients, hazard went from 0.1 to 0.2%. It means that 139 new patients developed Macular Degeneration during 3 years. I would really consider the benefits of GLP-1 versus health gains to diabetic patients (specially regarding quality of life with macular degeneration)

Re: Glucagon-Like Peptide-1 Receptor Agonists and Risk of Macular Degeneration

#3

Post by mh- » Wed, Jun 11, 2025, 2:45 PM UTC

> More than twice as many patients _with diabetes_ exposed to GLP-1 RAs developed nAMD compared to those in a matched cohort of similar patients who were unexposed.

Emphasis mine, but it's important context that probably wouldn't fit in the title.

Re: Glucagon-Like Peptide-1 Receptor Agonists and Risk of Macular Degeneration

#4

Post by blake929 » Wed, Jun 11, 2025, 2:47 PM UTC

* patients with diabetes

Re: Glucagon-Like Peptide-1 Receptor Agonists and Risk of Macular Degeneration

#5

Post by Mistletoe » Wed, Jun 11, 2025, 2:48 PM UTC

woliveirajr wrote: post #2

139,000 patients, hazard went from 0.1 to 0.2%. It means that 139 new patients developed Macular Degeneration during 3 years. I would really consider the benefits of GLP-1 versus health gains to diabetic patients (specially regarding quality of life with macular degeneration)

Yeah I would not even consider this on my radar if I was overweight. The health risks from obesity are so far in excess of this.

Re: Glucagon-Like Peptide-1 Receptor Agonists and Risk of Macular Degeneration

#6

Post by declan_roberts » Wed, Jun 11, 2025, 2:51 PM UTC

It's important to note that macular degeneration is caused by diabetes. So what would the rate of degeneration be without GLP-1s helping control blood sugar? My guess is much, much higher.

Re: Glucagon-Like Peptide-1 Receptor Agonists and Risk of Macular Degeneration

#7

Post by davikr » Wed, Jun 11, 2025, 2:51 PM UTC

> patients with diabetes

Re: Glucagon-Like Peptide-1 Receptor Agonists and Risk of Macular Degeneration

#8

Post by arp242 » Wed, Jun 11, 2025, 2:53 PM UTC

woliveirajr wrote: post #2

139,000 patients, hazard went from 0.1 to 0.2%. It means that 139 new patients developed Macular Degeneration during 3 years. I would really consider the benefits of GLP-1 versus health gains to diabetic patients (specially regarding quality of life with macular degeneration)

Probably depends on your situation; if you're obese: absolutely. If you're just a bit overweight, perhaps not?

Of course hard to extrapolate to the general case from this study, as it only included patients over 66 with a diagnosis of diabetes.

Re: Glucagon-Like Peptide-1 Receptor Agonists and Risk of Macular Degeneration

#9

Post by [deleted] » Wed, Jun 11, 2025, 2:55 PM UTC

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Re: Glucagon-Like Peptide-1 Receptor Agonists and Risk of Macular Degeneration

#10

Post by bicx » Wed, Jun 11, 2025, 2:56 PM UTC

declan_roberts wrote: post #6

It's important to note that macular degeneration is caused by diabetes. So what would the rate of degeneration be without GLP-1s helping control blood sugar? My guess is much, much higher.

Based on some quick research, macular degeneration can be a higher risk for diabetics that also have diabetic retinopathy. Study from 2018: https://diabetesjournals.org/care/article/41/10/2202/36669/T...