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Paxlovid: You'd have expected more

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Re: Paxlovid: You'd have expected more

#2
Always enjoy Derek Lowe's writing.

n=1 here, though I've heard others say the same -- but I (fairly healthy 30s male, vaccinated) found Paxlovid massively reduced symptom intensity for me. Within a day my symptoms went from "top 5 fevers I've ever experienced, normal function significantly impaired" to "feels like a cold; can reasonably handle myself around the house and even take a software engineering interview".

I most likely would not have got a severe infection and probably would not have got Long Covid, given my age / health / vaccine status, even if I hadn't taken it; but nonetheless I'm glad I was able to get it. Definitely worth it for the weird taste (hard candy helps).

Re: Paxlovid: You'd have expected more

#4
I don't have any insight into hospitalizations, but as someone who was not vaccinated at the time I came down with COVID-19, Paxlovid was the difference between feeling utterly horrible and barely being able to get out of bed to being able to work remotely at full productivity. I took the first dose on the first morning and by the next morning the difference was night and day. I too experienced the bizarre changes in flavors, but that was a very small price to pay for immediately ending my symptoms. I still did the full quarantine duration, but the quality of life was so much better!

Re: Paxlovid: You'd have expected more

#5
post #2

Always enjoy Derek Lowe's writing. n=1 here, though I've heard others say the same -- but I (fairly healthy 30s male, vaccinated) found Paxlovid massively reduced symptom intensity for me. Within a day my symptoms went from "top 5 fevers I've ever experienced, normal function significantly impaired" to "feels like a cold; can reasonably handle myself around the house and even take a software engineering interview". I…

n=2, same, generally healthy 28yo male, basically identical anecdote.

maybe technically n=3 since I've taken it twice!

Re: Paxlovid: You'd have expected more

#6
post #2

Always enjoy Derek Lowe's writing. n=1 here, though I've heard others say the same -- but I (fairly healthy 30s male, vaccinated) found Paxlovid massively reduced symptom intensity for me. Within a day my symptoms went from "top 5 fevers I've ever experienced, normal function significantly impaired" to "feels like a cold; can reasonably handle myself around the house and even take a software engineering interview". I…

Both times I had COVID I went from "worst fever ever / my body feels like I've been hit my a bus" to "I have a pretty average cold" in less than 36 hours. Utterly bizarre. (Vaccinated, good health, 40s male)

Edit to clarify: I didn't take anything other than paracetamol and ibuprofen.

Re: Paxlovid: You'd have expected more

#9
post #2

Always enjoy Derek Lowe's writing. n=1 here, though I've heard others say the same -- but I (fairly healthy 30s male, vaccinated) found Paxlovid massively reduced symptom intensity for me. Within a day my symptoms went from "top 5 fevers I've ever experienced, normal function significantly impaired" to "feels like a cold; can reasonably handle myself around the house and even take a software engineering interview". I…

Interestingly I had the weird side effect of going from COVID fever to low body temperature by my 2nd-3rd day of Paxlovid. If I remember correctly, it was in 95F-96F range.

My doc advised to stop taking it, but after reading on Reddit that a few others had had similar experience, decided to finish the entire treatment.

Re: Paxlovid: You'd have expected more

#10
post #4

I don't have any insight into hospitalizations, but as someone who was not vaccinated at the time I came down with COVID-19, Paxlovid was the difference between feeling utterly horrible and barely being able to get out of bed to being able to work remotely at full productivity. I took the first dose on the first morning and by the next morning the difference was night and day. I too experienced the bizarre changes in…

Same. I had one night of fever and incredible chills. Thought for sure I was going to get very sick. Got Paxlovid next day. Felt better the following day. It was like having a cold, and I don't think that would have happened without the Paxlovid.
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