Diets high in advanced glycation end products promote insulin resistance
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Re: Diets high in advanced glycation end products promote insulin resistance
#2Original paper: https://pubmed.ncbi.nlm.nih.gov/39320860/
Re: Diets high in advanced glycation end products promote insulin resistance
#3For others who also don't know what advanced glycation end-products are/are a bit confused by the headline:
https://en.m.wikipedia.org/wiki/Advanced_glycation_end-produ...
Found in humans, they are bio markers for quite a few diseases, including diabetes (type 2 = insulin resistance).
Food sources are animal products.
Wiki says vegetarians have been shown to have more than non-vegetarians, discounting dietary reasons for high levels in humans. This study suggests otherwise.
Re: Diets high in advanced glycation end products promote insulin resistance
#4For the uninitiated in Advanced Glycation Ends (AGEs):
> AGEs can also be ingested from food, especially food cooked at high temperatures and with little moisture, like grilled meats, fried foods, and baked goods.[23] The Maillard reaction is the main nonenzymatic reaction known to form AGEs in cooking and is famously known for the distinct browning color and complex flavor and aroma of roasted coffee, French fries, seared meat, and other favorites.
Re: Diets high in advanced glycation end products promote insulin resistance
#5For the uninitiated in Advanced Glycation Ends (AGEs): > AGEs can also be ingested from food, especially food cooked at high temperatures and with little moisture, like grilled meats, fried foods, and baked goods.[23] The Maillard reaction is the main nonenzymatic reaction known to form AGEs in cooking and is famously known for the distinct browning color and complex flavor and aroma of roasted coffee, French fries,…
In short, if it tastes nice and was man-processed, it probably will be bad for you?
Re: Diets high in advanced glycation end products promote insulin resistance
#6For others who also don't know what advanced glycation end-products are/are a bit confused by the headline: https://en.m.wikipedia.org/wiki/Advanced_glycation_end-produ... Found in humans, they are bio markers for quite a few diseases, including diabetes (type 2 = insulin resistance). Food sources are animal products. Wiki says vegetarians have been shown to have more than non-vegetarians, discounting dietary reasons…
The infographic in the article suggests they occur in aged cheeses, fried foods (including chips and french fries), roasted nuts (including peanut butter), and seared tofu. I believe those are all vegetarian staples.
Re: Diets high in advanced glycation end products promote insulin resistance
#7This definition of AGEs is interesting (linked from the article, same site):
"Advanced glycation end products (AGEs) form when proteins and fats (lipids) in the body react with sugar (glucose) and become glycated and oxidized."
So, maybe it's not so much the Maillard reaction but that sweetened brioche bun used in your fancy hamburger.
Re: Diets high in advanced glycation end products promote insulin resistance
#8For the uninitiated in Advanced Glycation Ends (AGEs): > AGEs can also be ingested from food, especially food cooked at high temperatures and with little moisture, like grilled meats, fried foods, and baked goods.[23] The Maillard reaction is the main nonenzymatic reaction known to form AGEs in cooking and is famously known for the distinct browning color and complex flavor and aroma of roasted coffee, French fries,…
In short, if it tastes nice and was man-processed, it probably will be bad for you?
That's a good first-order approximation, but is missing some nuance.
An example they use is eggs: Pan-fried eggs are listed as high in AGEs, whereas scrambled eggs aren't. Admittedly my diet isn't the best, but I wouldn't have expected a meaningful difference between ordering my eggs scrambled vs sunnyside-up.
Or for meat, stewed meat would be healthier than roasted meat.
I'm suddenly curious about coffee, now that they mention it...
Re: Diets high in advanced glycation end products promote insulin resistance
#9For others who also don't know what advanced glycation end-products are/are a bit confused by the headline: https://en.m.wikipedia.org/wiki/Advanced_glycation_end-produ... Found in humans, they are bio markers for quite a few diseases, including diabetes (type 2 = insulin resistance). Food sources are animal products. Wiki says vegetarians have been shown to have more than non-vegetarians, discounting dietary reasons…
The infographic in the article suggests they occur in aged cheeses, fried foods (including chips and french fries), roasted nuts (including peanut butter), and seared tofu. I believe those are all vegetarian staples.
The infographic also blames it on seared meats and fried eggs, so not exclusively an issue for vegetarians. The link to diet in general does seem a little tenuous though?
Re: Diets high in advanced glycation end products promote insulin resistance
#10For others who also don't know what advanced glycation end-products are/are a bit confused by the headline: https://en.m.wikipedia.org/wiki/Advanced_glycation_end-produ... Found in humans, they are bio markers for quite a few diseases, including diabetes (type 2 = insulin resistance). Food sources are animal products. Wiki says vegetarians have been shown to have more than non-vegetarians, discounting dietary reasons…
Don't over-cook your food. AGEs, PAHs, etc. are all bad.