Psilocybin bests SSRI for major depression in first long-term comparison
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Re: Psilocybin bests SSRI for major depression in first long-term comparison
#2Taking LSD every few months was the best antidepressant I’ve ever tried and I’ve tried a bunch
Re: Psilocybin bests SSRI for major depression in first long-term comparison
#3Taking LSD every few months was the best antidepressant I’ve ever tried and I’ve tried a bunch
This is surely no surprise to anyone who's ever had a good trip. I'd love to do this in a proper, controlled therapy setting, I suspect it would do me the world of good.
Re: Psilocybin bests SSRI for major depression in first long-term comparison
#4I wonder how much of an uphill battle it will be to get psilocybin approved for therapeutic use compared to synthetic psilocybin analogues that are being trialed right now. Psilocybin can't be patented and it's already scheduled as a narcotic everywhere.
Re: Psilocybin bests SSRI for major depression in first long-term comparison
#5https://en.wikipedia.org/wiki/Selective_serotonin_reuptake_i...
>Post-SSRI sexual dysfunction (PSSD)[62][63] refers to a set of symptoms reported by some people who have taken SSRIs or other serotonin reuptake-inhibiting (SRI) drugs, in which sexual dysfunction symptoms persist for at least three months[64][65][66] after ceasing to take the drug. The status of PSSD as a legitimate and distinct pathology is contentious; several researchers have proposed that it should be recognized as a separate phenomenon from more common SSRI side effects.[67]
>The reported symptoms of PSSD include reduced sexual desire or arousal, erectile dysfunction in males or loss of vaginal lubrication in females, difficulty having an orgasm or loss of pleasurable sensation associated with orgasm, and a reduction or loss of sensitivity in the genitals or other erogenous zones. Additional non-sexual symptoms are also commonly described, including emotional numbing, anhedonia, depersonalization or derealization, and cognitive impairment.[64][68] The duration of PSSD symptoms appears to vary among patients, with some cases resolving in months and others in years or decades;
At least, the mushroom didn't steal my mojo
Re: Psilocybin bests SSRI for major depression in first long-term comparison
#6This has been common knowledge among mushroom friends for a long time now. But it's always nice when the mainstream population gets "something official" that helps them open up to knowledge that is otherwise being censored quite everywhere.
Also, SSRI can definitely kill your sex life - and by extension your relationship(s) as well. And not just short-term (physiological changes have been observed). SSRIs have never been the best option (except for pharmaceutical companies).
Re: Psilocybin bests SSRI for major depression in first long-term comparison
#7It’s a neat study. I don’t know how you account for the intense placebo effect of a psychedelic experience for six hours though. We know that traditional antidepressants may work through this method already where you feel “different” and fix yourself. Trials with an active placebo often have results very similar to antidepressants.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4172306/
I guess maybe it doesn’t even matter in the end as long as people feel better.
Re: Psilocybin bests SSRI for major depression in first long-term comparison
#8[dead]
Re: Psilocybin bests SSRI for major depression in first long-term comparison
#9I think a major criticism of how this study is designed is that it is not truly "blinded". I doubt many of the participants were unsure if they received psilocybin vs escitalopram.
That being said, there are a number of studies that suggest this is an effective treatment, so I hope this can become more available to those who need it. However, for treatment resistant depression (especially with a catatonia component), intranasal ketamine is very hard to beat. Only topped by ECT in my experience.
Re: Psilocybin bests SSRI for major depression in first long-term comparison
#10[deleted]