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Drinking alcohol reduces the body's natural GLP-1 activity by 34%

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Re: Drinking alcohol reduces the body's natural GLP-1 activity by 34%

#4
I was expecting to see this study as related to GLP-1 activity post a night of drinking, and therefore we'd understand the mechanism, as decreased sleep delays GLP-1 activity by 90 minutes (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3697408/)

I'd be keen to understand the pathway by which alcohol intake directly reduces GLP-1 activity.

Re: Drinking alcohol reduces the body's natural GLP-1 activity by 34%

#6
post #2

"These findings provide compelling evidence that acute alcohol consumption decreases GLP-1, a satiation signal, elucidating alcohol's 'apéritif' effect." This could increase hunger and cravings (including for more alcohol).

The double whammy is that alcohol is an extremely calorically dense substance.

Even worse, it is consumed in liquid form, which also bypasses some satiation mechanisms in the body.

There's a reason tour de France riders get most of their replacement calories in liquid form

Re: Drinking alcohol reduces the body's natural GLP-1 activity by 34%

#7
post #2

"These findings provide compelling evidence that acute alcohol consumption decreases GLP-1, a satiation signal, elucidating alcohol's 'apéritif' effect." This could increase hunger and cravings (including for more alcohol).

The double whammy is that alcohol is an extremely calorically dense substance. Even worse, it is consumed in liquid form, which also bypasses some satiation mechanisms in the body. There's a reason tour de France riders get most of their replacement calories in liquid form

Indeed the average base spirit has 2-3 calorie per millilitre. This is 5-6x the amount found in coca cola or pepsi. But then again, the quantities are also much less than when drinking soft drinks (hopefully).

Re: Drinking alcohol reduces the body's natural GLP-1 activity by 34%

#8
post #5

Which is interesting because there’s a lot of Mediterranean cultures that drink after every meal (lunch & dinner). And the reason is “for digestion”. So this would suggest the opposite effect is happening. Drinking actually hurts digestion.

> And the reason is “for digestion”.

This is an excuse a few use to justify drinking wine when they know it's "otherwise" unhealthy, but most people here who drink do so simply because they like it.

Re: Drinking alcohol reduces the body's natural GLP-1 activity by 34%

#9
post #8
post #5

Which is interesting because there’s a lot of Mediterranean cultures that drink after every meal (lunch & dinner). And the reason is “for digestion”. So this would suggest the opposite effect is happening. Drinking actually hurts digestion.

> And the reason is “for digestion”. This is an excuse a few use to justify drinking wine when they know it's "otherwise" unhealthy, but most people here who drink do so simply because they like it.

I like drinking, but of course this means I also like coming up with weird excuses for why to drink.

Re: Drinking alcohol reduces the body's natural GLP-1 activity by 34%

#10
post #5

Which is interesting because there’s a lot of Mediterranean cultures that drink after every meal (lunch & dinner). And the reason is “for digestion”. So this would suggest the opposite effect is happening. Drinking actually hurts digestion.

Fermenting grapes is different than any alcohol.
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