Lactate helps cancer cells resist chemotherapy
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Re: Lactate helps cancer cells resist chemotherapy
#2This is all I can read. Does the paper imply
that any exercise is bad?
“ Lactate helps cancer cells resist chemotherapy The molecule lactate is a waste product of the metabolism of sugar without oxygen — a metabolic pathway preferentially used by cancer cells to generate their energy. Metabolomics analysis reveals that lactate in tumour cells promotes resistance to chemotherapy, and sheds light on the molecular mechanism that underlies this unexpected role of lactate in cancer”
Re: Lactate helps cancer cells resist chemotherapy
#3This is all I can read. Does the paper imply that any exercise is bad? “ Lactate helps cancer cells resist chemotherapy The molecule lactate is a waste product of the metabolism of sugar without oxygen — a metabolic pathway preferentially used by cancer cells to generate their energy. Metabolomics analysis reveals that lactate in tumour cells promotes resistance to chemotherapy, and sheds light on the molecular mecha…
Re: Lactate helps cancer cells resist chemotherapy
#4This is all I can read. Does the paper imply that any exercise is bad? “ Lactate helps cancer cells resist chemotherapy The molecule lactate is a waste product of the metabolism of sugar without oxygen — a metabolic pathway preferentially used by cancer cells to generate their energy. Metabolomics analysis reveals that lactate in tumour cells promotes resistance to chemotherapy, and sheds light on the molecular mecha…
> Does the paper imply that any exercise is bad?
How did you leap from (anaerobic) exercise to just exercise?
Re: Lactate helps cancer cells resist chemotherapy
#5This is all I can read. Does the paper imply that any exercise is bad? “ Lactate helps cancer cells resist chemotherapy The molecule lactate is a waste product of the metabolism of sugar without oxygen — a metabolic pathway preferentially used by cancer cells to generate their energy. Metabolomics analysis reveals that lactate in tumour cells promotes resistance to chemotherapy, and sheds light on the molecular mecha…
Lactate accumulates in the body only during a high intensity exercise, which generates lactate faster than it can be consumed by oxidation (like a sprint for up to 400 m).
When the intensity of an exercise is low enough that you could sustain it for much more than a few minutes continuously, there should be no increased amount of lactate in the body.
Re: Lactate helps cancer cells resist chemotherapy
#6This is all I can read. Does the paper imply that any exercise is bad? “ Lactate helps cancer cells resist chemotherapy The molecule lactate is a waste product of the metabolism of sugar without oxygen — a metabolic pathway preferentially used by cancer cells to generate their energy. Metabolomics analysis reveals that lactate in tumour cells promotes resistance to chemotherapy, and sheds light on the molecular mecha…
> Does the paper imply that any exercise is bad? How did you leap from (anaerobic) exercise to just exercise?
I guess I didn’t process it.
Just got back from a 3 mile walk and had my first chemotherapy yesterday. A little panic set in. Sounds like walking is still good. Thanks
Re: Lactate helps cancer cells resist chemotherapy
#7Neither this article, nor the actual paper it is based on (https://www.nature.com/articles/d41586-024-02731-9#:~:text=T....) has any mention of exercise, and the title here seems to be editorialised to add in "Metabolic byproduct of anaerobic exercise".
Just because lactate is produced from anaerobic exercise and this study found that lactate was used by the cancer cells, doesn't automatically follow that the cancer cells can use the lacate produced from exercise.
Re: Lactate helps cancer cells resist chemotherapy
#8Neither this article, nor the actual paper it is based on ( https://www.nature.com/articles/d41586-024-02731-9#:~:text=T... .) has any mention of exercise, and the title here seems to be editorialised to add in "Metabolic byproduct of anaerobic exercise". Just because lactate is produced from anaerobic exercise and this study found that lactate was used by the cancer cells, doesn't automatically follow that the cance…
You’re right, I’ll edit it.
Re: Lactate helps cancer cells resist chemotherapy
#9Neither this article, nor the actual paper it is based on ( https://www.nature.com/articles/d41586-024-02731-9#:~:text=T... .) has any mention of exercise, and the title here seems to be editorialised to add in "Metabolic byproduct of anaerobic exercise". Just because lactate is produced from anaerobic exercise and this study found that lactate was used by the cancer cells, doesn't automatically follow that the cance…
You’re right, I’ll edit it.
Thanks.
Re: Lactate helps cancer cells resist chemotherapy
#10Neither this article, nor the actual paper it is based on ( https://www.nature.com/articles/d41586-024-02731-9#:~:text=T... .) has any mention of exercise, and the title here seems to be editorialised to add in "Metabolic byproduct of anaerobic exercise". Just because lactate is produced from anaerobic exercise and this study found that lactate was used by the cancer cells, doesn't automatically follow that the cance…
They're probably talking about the Warburg effect, not exercise. The body is complicated and just because exercise can produce lactate doesn't mean it has anything to do with this.