Alzheimer's disease may be inherited more often than previously known
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Re: Alzheimer's disease may be inherited more often than previously known
#2I'll have to read it again but I didn't notice where they ruled out environmental factors (read: epigenetics). The thing about families is they share environments, diet, habits, other norms, etc.
Re: Alzheimer's disease may be inherited more often than previously known
#3I'll have to read it again but I didn't notice where they ruled out environmental factors (read: epigenetics). The thing about families is they share environments, diet, habits, other norms, etc.
They haven't ruled out epigenetics causes, but they are talking about a very specific gene (APOE4) with an extremely strong correlation with Alzheimer's when two copies of the gene are present.
Re: Alzheimer's disease may be inherited more often than previously known
#4I'll have to read it again but I didn't notice where they ruled out environmental factors (read: epigenetics). The thing about families is they share environments, diet, habits, other norms, etc.
Yeah if it is a prion disease, it might be transmitted.
Re: Alzheimer's disease may be inherited more often than previously known
#5I'll have to read it again but I didn't notice where they ruled out environmental factors (read: epigenetics). The thing about families is they share environments, diet, habits, other norms, etc.
They haven't ruled out epigenetics causes, but they are talking about a very specific gene (APOE4) with an extremely strong correlation with Alzheimer's when two copies of the gene are present.
Does everybody with two copies get Alzheimer’s? If not, then there must be at least one additional ingredient / cause.
Re: Alzheimer's disease may be inherited more often than previously known
#6Earlier quoted context omitted.
They haven't ruled out epigenetics causes, but they are talking about a very specific gene (APOE4) with an extremely strong correlation with Alzheimer's when two copies of the gene are present.
Does everybody with two copies get Alzheimer’s? If not, then there must be at least one additional ingredient / cause.
> Not only were people with two copies of the APOE4 gene much more likely to develop the biological changes that lead to Alzheimer’s disease, similar to people with the other genetic forms of the disease, they were almost assured the diagnosis: Nearly 95% of the people in the studies with two copies of the APOE4 gene had the biology of Alzheimer’s disease by the time they were 82 years old.
Re: Alzheimer's disease may be inherited more often than previously known
#7I'll have to read it again but I didn't notice where they ruled out environmental factors (read: epigenetics). The thing about families is they share environments, diet, habits, other norms, etc.
I -think- this is a working shareable link https://www.nature.com/articles/s41591-024-02931-w
Re: Alzheimer's disease may be inherited more often than previously known
#8Earlier quoted context omitted.
Does everybody with two copies get Alzheimer’s? If not, then there must be at least one additional ingredient / cause.
> Not only were people with two copies of the APOE4 gene much more likely to develop the biological changes that lead to Alzheimer’s disease, similar to people with the other genetic forms of the disease, they were almost assured the diagnosis: Nearly 95% of the people in the studies with two copies of the APOE4 gene had the biology of Alzheimer’s disease by the time they were 82 years old.
What percentage of people have microplastics in their body? Or have been previously infected by common childhood illness? I’m not giving these as theories for Alzheimer’s etiology, but to show that some environmental factors are ubiquitous.
Just because an environmental factor is ubiquitous—-or is ubiquitous within the frame of some sampling bias for the study—-doesn’t mean we should conclude the cause does not exist.
Re: Alzheimer's disease may be inherited more often than previously known
#9This isn't really anything new, the paper is just proposing APOE4 homozygous Alzheimer's as a special category.
Re: Alzheimer's disease may be inherited more often than previously known
#10Earlier quoted context omitted.
> Not only were people with two copies of the APOE4 gene much more likely to develop the biological changes that lead to Alzheimer’s disease, similar to people with the other genetic forms of the disease, they were almost assured the diagnosis: Nearly 95% of the people in the studies with two copies of the APOE4 gene had the biology of Alzheimer’s disease by the time they were 82 years old.
What percentage of people have microplastics in their body? Or have been previously infected by common childhood illness ? I’m not giving these as theories for Alzheimer’s etiology, but to show that some environmental factors are ubiquitous. Just because an environmental factor is ubiquitous—-or is ubiquitous within the frame of some sampling bias for the study—-doesn’t mean we should conclude the cause does not exis…
If a person is given an IV line, wouldn't friction introduce micro plastics into their body?