First-in-human implantation of bionic device to halt Crohn's disease (2023)

This paper seems to describe the general strategy:

Neuronal regulation of the gut immune system and neuromodulation for treating inflammatory bowel disease https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8565205/

It would be incredible if it works, since it would avoid treatment with systemic immunosuppresives which can promote infection/cancer. However maybe there is still a local risk of the above?

I would also be concerned about the implant getting covered in nasty biofilms over time.

If this type of thing works, does that mean that medication that target the nerves might work against inflammatory disease?

Anecdotes aren't data. Cornhs disease is know to go into sponteneuous remission in around 10% of patients for no reason what so ever for years to dacades at a time.

So if you have batch of a thousand people each going from one fad diet to the next you'd get around 100 of them telling you very loudly that whatever flavour of the month cured them. The 900 who didn't just move to the next fad.

My two half-brothers have Crohn's. My step-sister's two boys have Crohn's.

I don't have Crohn's. She doesn't have Crohn's. There's research ongoing into the genetics of Crohn's.

Changing diet can help ameliorate the symptoms, but it won't cure it any better than "taking the air" in Switzerland will cure asthma. And stating so boldly that a "wrong diet" causes it? Just to reiterate, of five kids raised on the same diet, (me, my 2 half-brothers, my 2 step-siblings) two have it, three don't.

But sure, just eat some raw meat or drink some vegan juice, problem solved... ...are you actually fucking serious mate?

You obviously know nothing about Crohn's and your glib handwavey internet opinion of "Duh, just eat some meat and roots" is, well, so goddamn dumb and shallow it's actually offensive.

Wovon man nicht sprechen kann, darüber muss man schweigen. Whereof one cannot speak, thereof one must be silent.

I will just call my assistant to get the jet and shack ready in the Hamptons, and to cancel all my meetings!

I don’t think correlation = causation in your anecdote. Care to provide some examples of people who were “cured” of Crohns through diet alone?

I have had Crohns for nearly four years with it in remission for the last two years. Diet and other lifestyle changes did slightly improve symptoms, but the only things that have yielded profound change were Inflectra and prednisone.

I think for those who have Crohns bad enough where they’re facing surgeries or being on a biologic for quite some time, diet alone isn’t going to fix the damage inflammation has already done.