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Chronic Buckyball Administration Doubles Rat Lifespan

extremelongevity.net

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Re: Chronic Buckyball Administration Doubles Rat Lifespan

#3

Post by Tim-Boss »

Obviously not everything studied in Rat models scales well or is even effective at all in Humans, but the potential applications of this will surely raise a few eyebrows!

Interesting to note a daily diet of olive oil increased their average lifespan by 4 months alone! The Omega-3 fatty acids in it at a guess... but I wonder what the exact methods of action are for C60!

Re: Chronic Buckyball Administration Doubles Rat Lifespan

#5

Post by RoboTeddy »

jey wrote: post #2

But how much of that effect is explained by the olive oil?

There were three groups:

1. control (normal rats) - 22 month lifespan

2. olive oil rats - 26 month lifespan

3. olive oil + C60 rats - 42 month lifespan

So, only about 1/5th of the effect is explained by the olive oil.

Re: Chronic Buckyball Administration Doubles Rat Lifespan

#6

Post by signa11 »

hesdeadjim wrote: post #4
jey wrote: post #2

But how much of that effect is explained by the olive oil?

They had a plain olive oil control that increased the lifespan from 22 to 26 months, compared to 42 with the C60 + oil.

but, it also sez the following : "They also demonstrated that the compound is fully absorbed via the GI tract and totally eliminated from the body in 10 hours." so, not sure what causes the increase in life-span. although, the cryptic "attenuation of age-associated increases in oxidative stress" does hint at something, probably the effect that this combo causes as it is moving through the GI tract ?

Re: Chronic Buckyball Administration Doubles Rat Lifespan

#7

Post by EvilTerran »

I find myself a little sceptical of articles on a website called "extreme longevity", to be honest...

... also, skimming the linked paper, the largest sample I see is "sixty rats randomly divided into 10 groups of 6 rats". I'm not sure if that's really large enough to draw any solid conclusions, and I don't see any P-values for the lifespan data -- but I freely admit I'm neither any kind of biologist nor a stats expert, so I may be talking rubbish.

Re: Chronic Buckyball Administration Doubles Rat Lifespan

#8

Post by carbocation »

Article: http://extremelongevity.net/wp-content/uploads/C60-Fullerene...

The part getting the attention has to do with longevity; for that part of the article, data comes from "[t]hree groups of 6 rats".

This was a single experiment in which n=6 rats received the C60 ('buckyball') composition, n=6 received just the oil, and n=6 received water (which can cause adverse effects in rats). Interestingly, a protective effect of oil gavage in some rat strains has apparently been observed before ( http://www.ncbi.nlm.nih.gov/pubmed/3591539 ) but that's a bit of a distraction since the focus is on the C60.

All treatment stopped after a few months when the first control rat died. Given that the half life is 14h for peritoneal injection of this particular substance, there should have been nothing left of it after ~70h. How it continued to affect rat lifespan for several months afterward would require explanation.

Re: Chronic Buckyball Administration Doubles Rat Lifespan

#9

Post by hellweaver666 »

Tim-Boss wrote: post #3

Obviously not everything studied in Rat models scales well or is even effective at all in Humans, but the potential applications of this will surely raise a few eyebrows! Interesting to note a daily diet of olive oil increased their average lifespan by 4 months alone! The Omega-3 fatty acids in it at a guess... but I wonder what the exact methods of action are for C60!

If nothing else, I'm sure the thought of extending the life of their favourite pet would make a few rat owners happy!
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