Hacker News Board Hacker News, browsed like a classic message board
Live data from Hacker News

Study shows antibodies against PEG in 83% of the German population

mpip-mainz.mpg.de

Post reply on HN
Print view View original

1–10 of 169 posts

Re: Study shows antibodies against PEG in 83% of the German population

#2

Post by tjrgergw »

> It has long been known that people can form defenses and thus antibodies against viruses. But antibodies can also develop against polyethylene glycol (PEG), a substance used in cosmetics, food and medicine.

People can develop antibodies against things which are not foreign micro-organisms. TIL.

(Obvious once you think about it. What you really develop antibodies to are proteins on the surface of micro-organisms)

Well, talk about a worldview-changing moment.

Re: Study shows antibodies against PEG in 83% of the German population

#3

Post by chpatrick »

tjrgergw wrote: post #2

> It has long been known that people can form defenses and thus antibodies against viruses. But antibodies can also develop against polyethylene glycol (PEG), a substance used in cosmetics, food and medicine. People can develop antibodies against things which are not foreign micro-organisms. TIL. (Obvious once you think about it. What you really develop antibodies to are proteins on the surface of micro-organisms) We…

Isn't that what allergies are?

Re: Study shows antibodies against PEG in 83% of the German population

#4

Post by HPsquared »

tjrgergw wrote: post #2

> It has long been known that people can form defenses and thus antibodies against viruses. But antibodies can also develop against polyethylene glycol (PEG), a substance used in cosmetics, food and medicine. People can develop antibodies against things which are not foreign micro-organisms. TIL. (Obvious once you think about it. What you really develop antibodies to are proteins on the surface of micro-organisms) We…

In other words, allergies.

Re: Study shows antibodies against PEG in 83% of the German population

#5

Post by didgeoridoo »

tjrgergw wrote: post #2

> It has long been known that people can form defenses and thus antibodies against viruses. But antibodies can also develop against polyethylene glycol (PEG), a substance used in cosmetics, food and medicine. People can develop antibodies against things which are not foreign micro-organisms. TIL. (Obvious once you think about it. What you really develop antibodies to are proteins on the surface of micro-organisms) We…

I don’t think the news here is that PEG can be targeted by antibodies (research companies have been manufacturing anti-PEG antibodies for decades), but that anti-PEG arises naturally (and frequently!) in the adaptive immune system.

Might be a good biomarker to adjust dosing and estimated pharmacokinetics of PEGylated drugs; it might make sense to take another look at PEG-based therapies that failed Phase II/III with this new finding in mind?

Re: Study shows antibodies against PEG in 83% of the German population

#7

Post by ekianjo »

s5ma6n wrote: post #6

Apparently PEG is/was the one of the reasons of the severe allergic reactions in mRNA COVID-19 vaccines (Moderna, Pfizer)[0] That's plastics for you folks... [0]: [Translated from German]( https://www-aerzteblatt-de.translate.goog/archiv/217236/COVI... )

PEG is not plastics...

Re: Study shows antibodies against PEG in 83% of the German population

#9

Post by s5ma6n »

ekianjo wrote: post #7
s5ma6n wrote: post #6

Apparently PEG is/was the one of the reasons of the severe allergic reactions in mRNA COVID-19 vaccines (Moderna, Pfizer)[0] That's plastics for you folks... [0]: [Translated from German]( https://www-aerzteblatt-de.translate.goog/archiv/217236/COVI... )

PEG is not plastics...

It is a petroleum-based polymer, tomato vs tomato...
Post reply on HN