Human embryo models grown from stem cells
wis-wander.weizmann.ac.il
Human embryo models grown from stem cells
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Re: Human embryo models grown from stem cells
#2A team of scientists at the Weizmann Institute have successfully created an 'embryo model' that closely resembles a 14-day-old human embryo, without using sperm, eggs or womb.
Re: Human embryo models grown from stem cells
#3A team of scientists at the Weizmann Institute have successfully created an 'embryo model' that closely resembles a 14-day-old human embryo, without using sperm, eggs or womb.
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Re: Human embryo models grown from stem cells
#4A team of scientists at the Weizmann Institute have successfully created an 'embryo model' that closely resembles a 14-day-old human embryo, without using sperm, eggs or womb.
The question I have is why they call it a model?
It is certainly not a simulation, and although it apparently started with different components they manipulated those to behave the way the normal versions do.
What would happen if they implanted it in a womb?
Re: Human embryo models grown from stem cells
#5A team of scientists at the Weizmann Institute have successfully created an 'embryo model' that closely resembles a 14-day-old human embryo, without using sperm, eggs or womb.
The question I have is why they call it a model? It is certainly not a simulation, and although it apparently started with different components they manipulated those to behave the way the normal versions do. What would happen if they implanted it in a womb?
It’s a model because it’s not completely equivalent. Medicine has learned a great deal from studying rodents, but humans are quite different.
For one thing human embryos would have already been implanted in a womb for a week at that point and a great deal of signaling occurs between embryo and the uterus.
Re: Human embryo models grown from stem cells
#6It's one of the two publications that raised a controversy in June, for example discussed here: https://news.ycombinator.com/item?id=36330732
A summary on Nature news at the times: https://archive.ph/Xnx5n
Re: Human embryo models grown from stem cells
#7Earlier quoted context omitted.
The question I have is why they call it a model? It is certainly not a simulation, and although it apparently started with different components they manipulated those to behave the way the normal versions do. What would happen if they implanted it in a womb?
It’s a model because it’s not completely equivalent. Medicine has learned a great deal from studying rodents, but humans are quite different. For one thing human embryos would have already been implanted in a womb for a week at that point and a great deal of signaling occurs between embryo and the uterus.
Signalling? Thank you for expanding my horizons. Could you please share some more? Even a link or two would suffice.
Re: Human embryo models grown from stem cells
#8I used to be a researcher in NLP until not too long ago. Over the last few years, increasing pressure has been put on on everyone trying to publish papers related to training data collected through human trials to provide ethics statements as a way to ensure that certain standards are met regarding that data. Not everyone is able to see too much sense in this process, and I've heard comments from non-US colleagues that it reflects a purely American world view. But I think that there are at least some applications where ethical consideration are definitely worth talking about, eg., in applications such as hate speech detection.
And of course, even if you don't agree with the necessity for ethics statements, because it is just one more thing that takes up time you could otherwise spend on your actual job (doing research), you certainly don't want to risk having your paper rejected just because you don't meet whatever ethics standards the conference or journal seeks to uphold.
But remember, I'm talking natural language processing here.
In that light, it is a complete mystery to me how research like the one described in the article could have possibly, ever made it past an ethics review. Unless, of course, completely different standards are applied - which in itself would be rather questionable.
Re: Human embryo models grown from stem cells
#9[dead]
Re: Human embryo models grown from stem cells
#10Earlier quoted context omitted.
It’s a model because it’s not completely equivalent. Medicine has learned a great deal from studying rodents, but humans are quite different. For one thing human embryos would have already been implanted in a womb for a week at that point and a great deal of signaling occurs between embryo and the uterus.
Signalling? Thank you for expanding my horizons. Could you please share some more? Even a link or two would suffice.
I am not expert but I think OP means different hormones would start to get produced and others would become suppressed to support the creation of a placenta, to support the the lining of the uterus and to cease ovulation and menstrual cycle as well as to start supporting the growing embryo in terms of nutrients by means of generating and connecting blood vessels.
I read somewhere that pregnancy (unlike what is normally described) is a tug of war between the embryo which is the leach if you will on the mother which is the host. The embryo basically try consumes the host and so long as everybody is doing what they're supposed to, all the mechanisms end up keeping that war at bay with both participants making it alive at the end. If some mechanisms (and signals) were to misbehave one of the two would cease to exist.