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Time-restricted eating reshapes gene expression throughout the body

sciencedaily.com

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Re: Time-restricted eating reshapes gene expression throughout the body

#4

Post by mrandish »

Notes:

- In mice.

- Tested 16:8 pattern.

- Sustained consistently for nine weeks.

- No exploration in this study of the effects and/or benefits from the gene expression.

N=1 but I've been doing ~16:8-ish along with strict keto for the past five years and the net benefits for me have been transformative in fitness (Weight: -100+ lbs, BMI: Obese->Fit), long-term health (A1C, LDL/HDL, Trigs, BP, resting heart rate all from bad to great), cognitive acuity and emotional stability. First 12 weeks required serious effort/focus to transition habits, palette and metabolism (must RTFM and be rigorous) but after that it's been surprisingly easy to sustain long-term, requiring no will power or conscious effort.

Other surprising experiential learnings: Dietary intake impacts long-term mental/emotional states FAR more than I ever suspected. Food & taste prefs I had since childhood are not innate. Many things I loved no longer even taste good. Hunger pangs and cravings are driven by my blood sugar cycle. Once I stabilized that I no longer get hungry or feel food deprived/obsessed. (<--- all N=1 of course.)

Re: Time-restricted eating reshapes gene expression throughout the body

#5

Post by yonibot »

mrandish wrote: post #4

Notes: - In mice. - Tested 16:8 pattern. - Sustained consistently for nine weeks. - No exploration in this study of the effects and/or benefits from the gene expression. N=1 but I've been doing ~16:8-ish along with strict keto for the past five years and the net benefits for me have been transformative in fitness (Weight: -100+ lbs, BMI: Obese->Fit), long-term health (A1C, LDL/HDL, Trigs, BP, resting heart rate all f…

N=1 and also probably too many variables to learn from this - keto itself is already a massive lifestyle intervention. Did you restrict calories as well? Exercise?

Re: Time-restricted eating reshapes gene expression throughout the body

#6

Post by karim79 »

mrandish wrote: post #4

Notes: - In mice. - Tested 16:8 pattern. - Sustained consistently for nine weeks. - No exploration in this study of the effects and/or benefits from the gene expression. N=1 but I've been doing ~16:8-ish along with strict keto for the past five years and the net benefits for me have been transformative in fitness (Weight: -100+ lbs, BMI: Obese->Fit), long-term health (A1C, LDL/HDL, Trigs, BP, resting heart rate all f…

Out of curiosity, and if you don't mind me asking, what is your daily carb intake while doing keto?

Re: Time-restricted eating reshapes gene expression throughout the body

#7

Post by hellosputnik »

mrandish wrote: post #4

Notes: - In mice. - Tested 16:8 pattern. - Sustained consistently for nine weeks. - No exploration in this study of the effects and/or benefits from the gene expression. N=1 but I've been doing ~16:8-ish along with strict keto for the past five years and the net benefits for me have been transformative in fitness (Weight: -100+ lbs, BMI: Obese->Fit), long-term health (A1C, LDL/HDL, Trigs, BP, resting heart rate all f…

Is your 16:8 restricted to a full meal or did you consume or drink anything outside of the 16:8? After-work drinks? Coffee?

Re: Time-restricted eating reshapes gene expression throughout the body

#8

Post by cush »

There's an excellent Huberman Lab episode that covers various studies on time restricted eating for both mice and humans. There's a high focus on cognitive, health, and sleep benefits in humans.

https://hubermanlab.com/effects-of-fasting-and-time-restrict...

Re: Time-restricted eating reshapes gene expression throughout the body

#9

Post by throwawaycities »

mrandish wrote: post #4

Notes: - In mice. - Tested 16:8 pattern. - Sustained consistently for nine weeks. - No exploration in this study of the effects and/or benefits from the gene expression. N=1 but I've been doing ~16:8-ish along with strict keto for the past five years and the net benefits for me have been transformative in fitness (Weight: -100+ lbs, BMI: Obese->Fit), long-term health (A1C, LDL/HDL, Trigs, BP, resting heart rate all f…

There are also studies showing both keto diets and fasting can alter the microbiome and attributed changes in gene expression to changes in the microbiome.
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