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Long Covid: major findings, mechanisms and recommendations

nature.com

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Re: Long Covid: major findings, mechanisms and recommendations

#2
Interesting that they classify loss of smell as a neurological symptom. I had Covid last January and my sense of smell has never been the same. I used to be able to walk into a room, flair my nostrils, and pick up everything from the couch, carpet, and curtains… to the subtle cool drafts from the windows and fireplace. Now everything has completely dulled out, and I only occasionally pick up those old scents in passing - functioning as a cruel reminder of what I lost.

Re: Long Covid: major findings, mechanisms and recommendations

#4
Unease and woe are the two feelings I'm left with after my quick layman reading of the article.

Think I am most concerned with the reproductive implications, which seem under researched. Coupled with the unrelated decline in sperm count the past decade... I'm hoping my ruminations are just me catastrophizing.

Can anyone more medically and scientifically literate provide some context to temper my doom and gloom?

Re: Long Covid: major findings, mechanisms and recommendations

#5
As always, it is difficult to assess this sort of thing without a reference to the flu. As far as I can tell, in daily life we are continuously encountering people with various chronic problems and systemically under-calling the impact of them. It is a total coincidence if a body is functioning at full capacity.

If COVID increases the hazard ratios there isn't much I can do. As far as I can tell, everyone is going to get COVID. There is no avoiding that. It would be interesting to know how much worse it is than a typical flu though, just for academic interest.

Re: Long Covid: major findings, mechanisms and recommendations

#6
post #2

Interesting that they classify loss of smell as a neurological symptom. I had Covid last January and my sense of smell has never been the same. I used to be able to walk into a room, flair my nostrils, and pick up everything from the couch, carpet, and curtains… to the subtle cool drafts from the windows and fireplace. Now everything has completely dulled out, and I only occasionally pick up those old scents in passi…

That's fascinating - even as a kid my sense of smell has been near-nonexistent. Whenever I've read descriptions of powerful smells in books, I've always written them off as overly flowery language.

Reminds me a little generally of how some have an inner voice when they read and others don't.

Re: Long Covid: major findings, mechanisms and recommendations

#7
Fascinating read.

I'm glad to see these findings get serious attention by researchers. It was really frustrating getting dismissed by my local physician when sharing symptoms like sugar sensitivity, fatigue, and focus issues. It was like being perpetually tipsy for months. It was a big shock as a knowledge worker to have to relearn how focus.

I hope they further study vaccines as well. In my anecdotal case my long covid symptoms resumed, along with additional symptoms like body bruising / bone pain for several weeks. There may be classes of healthy adults that react differently than expected and we can learn how to improve from the evidence.

Re: Long Covid: major findings, mechanisms and recommendations

#8
post #4

Unease and woe are the two feelings I'm left with after my quick layman reading of the article. Think I am most concerned with the reproductive implications, which seem under researched. Coupled with the unrelated decline in sperm count the past decade... I'm hoping my ruminations are just me catastrophizing. Can anyone more medically and scientifically literate provide some context to temper my doom and gloom?

> Can anyone more medically and scientifically literate provide some context to temper my doom and gloom?

Most of these issues stem back to endothelium damage. And the good news is that, in addition to taking all the vaccines you're eligible to get, there are a bunch of other things you can do to strengthen and protect your endothelium, e.g. doing HIIT and taking ACE inhibitors. The one risk we (afaik) don't really know how to mitigate is the risk of developing an autoimmune disorder, but this can happen after any viral illness and isn't necessarily a COVID-specific risk.

And in terms of reducing the risk of neurological issues, Palmitoylethanolamide seems to a least be much safer than NSAIDs, albeit expensive and still somewhat experimental.

Re: Long Covid: major findings, mechanisms and recommendations

#9
post #2

Interesting that they classify loss of smell as a neurological symptom. I had Covid last January and my sense of smell has never been the same. I used to be able to walk into a room, flair my nostrils, and pick up everything from the couch, carpet, and curtains… to the subtle cool drafts from the windows and fireplace. Now everything has completely dulled out, and I only occasionally pick up those old scents in passi…

How is your taste? I lost it completely (not just a little or muted, but 100% gone) for about 5 weeks. It started to come back, but 18 months later things still don't taste right. Nothing is flavorful or stands out as delicious.

Re: Long Covid: major findings, mechanisms and recommendations

#10
Covid fatigue is no joke.

As an Elite Athlete I'm training 20-30 hours a week. I got covid last year (triple vaxed) and it wiped me out for a good 6 months. It took me 3 weeks to be able to walk longer than a minute without needing to lay down for the rest of the day and sleep.

I have dealt with fatigue problems for 6 months and only just now, do I feel like I'm getting "back to normal".

The most frustrating thing is alot of people are dismissive of the symptoms and generally say, "Oh yeah, I get tired too" but fail to understand the severity of it as they haven't experienced it.

I have a fairly good understanding of my body and the associated symptoms of overtraining/fatigue in a heavy training cycle but covid fatigue was soemthing completely different.

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