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Schizophrenia: The new etiological synthesis

sciencedirect.com

1–10 of 128 posts

Re: Schizophrenia: The new etiological synthesis

#2
Parasite based, interesting.

Half joking but the shift from understanding szr as an intrinsic psychological condition versus being causally related to parasites remind me hilariously of the midichlorians reveal in star wars.

Re: Schizophrenia: The new etiological synthesis

#3
Okay, this is fascinating.

The fact that “schizophrenia is rare or nonexistent in hunter-gatherer populations” is particularly interesting.

I had no idea this was the case.

Clearly there is much more research to be done, but I feel like the authors are on the right track here.

Re: Schizophrenia: The new etiological synthesis

#4
post #2

Parasite based, interesting. Half joking but the shift from understanding szr as an intrinsic psychological condition versus being causally related to parasites remind me hilariously of the midichlorians reveal in star wars.

I think we'll probably see a lot of this kind of synthesis as our ability to model grows stronger.

Seeing yourself as a collection of billions of separate but symbiotic, sometimes competing organisms rather than as one coherent one is a big paradigm shift which will likely result in a lot of fruitful theories and hopefully eventually treatments for disease and illness.

Crucially, we're getting to a place where we can model some of this and then directly attack several other pieces which were inaccessible to us before due to sheer amount of complexity.

Re: Schizophrenia: The new etiological synthesis

#5
post #2

Parasite based, interesting. Half joking but the shift from understanding szr as an intrinsic psychological condition versus being causally related to parasites remind me hilariously of the midichlorians reveal in star wars.

Also similar to the Epstein-Barr virus link to MS

Re: Schizophrenia: The new etiological synthesis

#6
Wasn't schizophrenia identified as basically off-by-one (multiple?) error of the deletion algorithm in the brain that is garbage collecting more (glial?) cells in a row than needed during teenage years? And "overclocking" glial cells by adding large quantities of Niacin/NAD+ partially alleviates those symptoms?

Re: Schizophrenia: The new etiological synthesis

#10
"Living in an urban environment during childhood or as an adult has consistently been found to increase the risk of schizophrenia by a factor of two."[0] While city life is as complex of a confounding factor as anything, the fact that they found hunter-gatherers have practically no incidence of SZR is interesting. Is the modern megalopolis simply too intense of a stimulus for the minds of the sensitive to handle without splitting into pieces?

[0] https://en.wikipedia.org/wiki/Schizophrenia#Environmental

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