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Mouse embryo with brain and beating heart created from stem cells

cambridgeindependent.co.uk

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Re: Mouse embryo with brain and beating heart created from stem cells

#2
This really is pretty amazing work. But, to the uninitiated, there's a dark side; I overheard someone commenting about an earlier post about this experiment, thinking it's possible to get out a chemistry set and just make a living thing. To be clear, they started with stem cells, and teased them into doing the right thing - they did not create a new living artifact from scratch;

> Instead, they used stem cells - the body’s master cells, which can develop into almost any cell type - and then mimicked natural processes in the lab.

Re: Mouse embryo with brain and beating heart created from stem cells

#5
> to understand why so many pregnancies fail and how we might be able to prevent that from happening

Are we sure that's a good idea? I've read that one of the reason for early pregnancy failure is that the embryo is not fit enough and it would be a waste of time and resources to commit to it.

Another very counterintuitive finding is that if you try to implant embryos in various tissues (brain, liver, ...), the one in which is the hardest is the uterus! Because it's actively fighting against the embryo.

Re: Mouse embryo with brain and beating heart created from stem cells

#7

> to understand why so many pregnancies fail and how we might be able to prevent that from happening Are we sure that's a good idea? I've read that one of the reason for early pregnancy failure is that the embryo is not fit enough and it would be a waste of time and resources to commit to it. Another very counterintuitive finding is that if you try to implant embryos in various tissues (brain, liver, ...), the one in…

The question is why is the embryo not “fit enough”. One way to increase the chance of success is by making the embryo “more fit”, but that requires an understanding of what that definition of fitness is, and that is what I understand this study is about.
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