Microbiome-driven effects of non-nutritive sweeteners on human glucose tolerance
1–10 of 75 posts
Re: Microbiome-driven effects of non-nutritive sweeteners on human glucose tolerance
#2A glance suggests that Saccharine and Sucralose may be problematic. The others may be “complicated” but the effect also looks close to noise. They should have included some non-sweetener molecules of a similar nature as controls.
Sucralose was an instant no to me when I saw the molecule. “Here let’s hang a chlorine off this here sugar.” Nope. I recall seeing similar sentiments in a thread over at Reddit where a biochemist remarked that it looked like a pesticide.
The weird complicated molecules in Stevia and Monk Fruit seem safe precisely because they look like something the body is going to hack apart right away and look like all the other complicated molecules found in plants that the body is used to dealing with. Things like blueberries and onions are just loaded with random baroque carbon sculptures like this.
Re: Microbiome-driven effects of non-nutritive sweeteners on human glucose tolerance
#3A glance suggests that Saccharine and Sucralose may be problematic. The others may be “complicated” but the effect also looks close to noise. They should have included some non-sweetener molecules of a similar nature as controls. Sucralose was an instant no to me when I saw the molecule. “Here let’s hang a chlorine off this here sugar.” Nope. I recall seeing similar sentiments in a thread over at Reddit where a bioch…
As someone that is relying on a single high school chemistry class as a base of knowledge, why would Cl here give you pause? In other words why is the Cl here bad, but ok in say salt?
Re: Microbiome-driven effects of non-nutritive sweeteners on human glucose tolerance
#4Just wondering why sugar alcohols like sorbitol and erythritol were excluded from this study.
Re: Microbiome-driven effects of non-nutritive sweeteners on human glucose tolerance
#5A glance suggests that Saccharine and Sucralose may be problematic. The others may be “complicated” but the effect also looks close to noise. They should have included some non-sweetener molecules of a similar nature as controls. Sucralose was an instant no to me when I saw the molecule. “Here let’s hang a chlorine off this here sugar.” Nope. I recall seeing similar sentiments in a thread over at Reddit where a bioch…
As someone that is relying on a single high school chemistry class as a base of knowledge, why would Cl here give you pause? In other words why is the Cl here bad, but ok in say salt?
As another person with only high school chemistry, sucralose does look a bit like DDT.
https://en.m.wikipedia.org/wiki/DDT https://en.m.wikipedia.org/wiki/Sucralose
Re: Microbiome-driven effects of non-nutritive sweeteners on human glucose tolerance
#6Just wondering why sugar alcohols like sorbitol and erythritol were excluded from this study.
By messing with part of the fructose transport mechanisms sugar alcohols are messing with the microbiome so likely would have stood out. There is a reason at least here there are labels warning of too much consumption.
Re: Microbiome-driven effects of non-nutritive sweeteners on human glucose tolerance
#7A glance suggests that Saccharine and Sucralose may be problematic. The others may be “complicated” but the effect also looks close to noise. They should have included some non-sweetener molecules of a similar nature as controls. Sucralose was an instant no to me when I saw the molecule. “Here let’s hang a chlorine off this here sugar.” Nope. I recall seeing similar sentiments in a thread over at Reddit where a bioch…
As someone that is relying on a single high school chemistry class as a base of knowledge, why would Cl here give you pause? In other words why is the Cl here bad, but ok in say salt?
Chlorine-carbon (or halocarbons in general) bonds are somewhat rare in nature. That is not to say they don't exist, but they are a bit unusual. The problem with halocarbons (aside from fluorine, which has its own issues) is they are generally not very reactive, so they can bioaccumulate. But when they do react with biological systems, it tends to be in unwanted and toxic ways.
That said, as a former chemist, I consume sucralose, and I am not worried by it. Unlike most halocarbons, It's very water soluble, so it does not react in the ways the bad halocarbons do.
Re: Microbiome-driven effects of non-nutritive sweeteners on human glucose tolerance
#8Earlier quoted context omitted.
As someone that is relying on a single high school chemistry class as a base of knowledge, why would Cl here give you pause? In other words why is the Cl here bad, but ok in say salt?
As another person with only high school chemistry, sucralose does look a bit like DDT. https://en.m.wikipedia.org/wiki/DDT https://en.m.wikipedia.org/wiki/Sucralose
In the grand scheme of molecules, they look nothing alike.
DDT is what we call a "greasy brick", while sucralose is a highly water soluble sugar.
Re: Microbiome-driven effects of non-nutritive sweeteners on human glucose tolerance
#9A glance suggests that Saccharine and Sucralose may be problematic. The others may be “complicated” but the effect also looks close to noise. They should have included some non-sweetener molecules of a similar nature as controls. Sucralose was an instant no to me when I saw the molecule. “Here let’s hang a chlorine off this here sugar.” Nope. I recall seeing similar sentiments in a thread over at Reddit where a bioch…
As someone that is relying on a single high school chemistry class as a base of knowledge, why would Cl here give you pause? In other words why is the Cl here bad, but ok in say salt?
In salts and in sea water, the chlorine is in the form of free chloride ions, which is also the normal form of chlorine in your body.
In sucralose, chlorine substitutes a hydroxy group and it is covalently bonded to a carbon atom.
Most of the organic substances where hydroxy groups are substituted with chlorine atoms are more or less toxic and some are carcinogenic.
For example, substituting the hydroxy groups in carbonic acid with chlorine yields the toxic phosgene, which has been used as a chemical weapon in WWI.
Re: Microbiome-driven effects of non-nutritive sweeteners on human glucose tolerance
#10A glance suggests that Saccharine and Sucralose may be problematic. The others may be “complicated” but the effect also looks close to noise. They should have included some non-sweetener molecules of a similar nature as controls. Sucralose was an instant no to me when I saw the molecule. “Here let’s hang a chlorine off this here sugar.” Nope. I recall seeing similar sentiments in a thread over at Reddit where a bioch…
Everyone always with this "noise"! Of course there is noise! They are looking at the "noise" and telling you what it is from! Genetics!
If you average any trial out in a large population there will be "noise", but these people who live with the "noise" are the ones affected and suffering.
Does everyone have microbiome-driven effects of non-nutritive sweeteners? Probably not, but what about the ones that do?