‘Dancing molecules’ successfully repair severe spinal cord injuries
news.northwestern.edu
‘Dancing molecules’ successfully repair severe spinal cord injuries
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Re: ‘Dancing molecules’ successfully repair severe spinal cord injuries
#2I truly, truly hope this works as described, even partially, on humans. It is so frustrating to see someone who would be able to walk if only the signal could get to their lower extremities.
My grandfather is a paraplegic, and man how much I hope this isn't just faery dust.
Re: ‘Dancing molecules’ successfully repair severe spinal cord injuries
#3Again mice models...
Re: ‘Dancing molecules’ successfully repair severe spinal cord injuries
#4Again mice models...
Yes, as a logical first step.
Now we at least have hope this might work for humans.
Re: ‘Dancing molecules’ successfully repair severe spinal cord injuries
#5Re: ‘Dancing molecules’ successfully repair severe spinal cord injuries
#6Earlier quoted context omitted.
Yes, as a logical first step. Now we at least have hope this might work for humans.
Mice models have a very bad track record when it comes to humans. Too much junk publications out there to push papers and get credits.
You have to start somewhere though.
Re: ‘Dancing molecules’ successfully repair severe spinal cord injuries
#7Earlier quoted context omitted.
Mice models have a very bad track record when it comes to humans. Too much junk publications out there to push papers and get credits.
You have to start somewhere though.
I would guess things like how nerves and bones work is more similar across species than, say, how drugs might work on the brain, where a mouse brain is a hell of a lot different to human. Is that a reasonable assumption?
Re: ‘Dancing molecules’ successfully repair severe spinal cord injuries
#8Earlier quoted context omitted.
You have to start somewhere though.
I would guess things like how nerves and bones work is more similar across species than, say, how drugs might work on the brain, where a mouse brain is a hell of a lot different to human. Is that a reasonable assumption?
If there is a difference, we’ll learn what the difference is, and if there’s another one after that the same, and so on.
Re: ‘Dancing molecules’ successfully repair severe spinal cord injuries
#9Earlier quoted context omitted.
You have to start somewhere though.
I would guess things like how nerves and bones work is more similar across species than, say, how drugs might work on the brain, where a mouse brain is a hell of a lot different to human. Is that a reasonable assumption?
I was wondering the same thing. Pluses and minuses...
Rodents represent readily available models that can be used for a deeper understanding of basic biological mechanisms and for proof of concept for preclinical research hypotheses. However, attempts at direct clinical translation to humans have proven problematic or even impossible to date, principally due to issues of scaling and complexity.
https://clinmedjournals.org/articles/ijscrt/international-jo...
Re: ‘Dancing molecules’ successfully repair severe spinal cord injuries
#10Earlier quoted context omitted.
Yes, as a logical first step. Now we at least have hope this might work for humans.
Mice models have a very bad track record when it comes to humans. Too much junk publications out there to push papers and get credits.
I thought the main point of mouse models was mostly to be a "first pass filter" for substances before moving onto other animals usually, sometimes humans if the straits are desperate enough. Cancer drugs in particular have little concern for long term side effects in their approval pipeline because the alternative may be having no long term.