Ivermectin shows clinical benefits in mild to moderate COVID19: RCT double-blind
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Re: Ivermectin shows clinical benefits in mild to moderate COVID19: RCT double-blind
#2a) "In vitro studies have shown the efficacy of Ivermectin (IV) to inhibit the SARS—CoV-2 viral replication, but questions remained as to in-vivo applications" [0]
b) "Sixty-three patients with positive PCR result were randomized into three arms of the study. There was 1 withdrawal, thus 62 patients completed the study" [0]
c) "We cannot conclude in this study that Ivermectin has a place in prophylaxis, but this warrants investigation." [0]
[0] https://academic.oup.com/qjmed/advance-article/doi/10.1093/q...
Re: Ivermectin shows clinical benefits in mild to moderate COVID19: RCT double-blind
#3Trial group of 62 patients and no parasite screening in those patients - yawn. But could be interesting grounds for a more significant and controlled study with patients with comorbidities.
Re: Ivermectin shows clinical benefits in mild to moderate COVID19: RCT double-blind
#4The whole Ivermectin controversy has been so strange given that it's known to be safe. If it's effective great and if not then there's no harm.
Re: Ivermectin shows clinical benefits in mild to moderate COVID19: RCT double-blind
#5Please only take this medication by prescription from a medical doctor. Even if these results are replicated, there is a huge difference between 12mg/day IV for 5 days under medical supervision and consuming a tube of apple flavored paste containing 6 grams of ivermectin. Ivermectin is neurotoxic at high doses and can absolutely kill you.
Re: Ivermectin shows clinical benefits in mild to moderate COVID19: RCT double-blind
#6I saw a post on NIH studies showing possible benefits and people dismissing it because it wasn't a preponderance of evidence. Totally valid to dismiss a selected sample but made me realize there was more of a basis for its usage than, let's say, bleach.
That said, I was wrong, removed. I guess it's too much to ask for people to trust the recommended medicine, perhaps we should get more pro-vaccine conspiracy theories out there =/
Re: Ivermectin shows clinical benefits in mild to moderate COVID19: RCT double-blind
#7[deleted]
Re: Ivermectin shows clinical benefits in mild to moderate COVID19: RCT double-blind
#8The whole Ivermectin controversy has been so strange given that it's known to be safe. If it's effective great and if not then there's no harm.
If its effective it means there is a treatment available. If there is a treatment available in the beginning stages of ncov19 then the justification for EUA, by law, becomes invalid.
And pfizer and pharma companies lose billions and billions of dollars.
Hence why it has been so strange...
Re: Ivermectin shows clinical benefits in mild to moderate COVID19: RCT double-blind
#9Trial group of 62 patients and no parasite screening in those patients - yawn. But could be interesting grounds for a more significant and controlled study with patients with comorbidities.
Do we have any data on the base rate of parasite infections in Lagos?
Re: Ivermectin shows clinical benefits in mild to moderate COVID19: RCT double-blind
#10Trial group of 62 patients and no parasite screening in those patients - yawn. But could be interesting grounds for a more significant and controlled study with patients with comorbidities.
If you look on Twitter there are other methodological concerns people have with this study. The more important thing is just that it's relatively old, and there have been meta-analyses done; like, lots of people are studying the ivermectin question, and the weight of the evidence doesn't seem to be positive.
Here's Cochran's meta-study; Cochran is, from what I can tell, very well-regarded. It appears to include this study. https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD...
Later
For what it's worth: the boy rebuts this with the observation that you'd expect worsening symptoms for patients with actual parasitic infection, since there's an immune response to necrotic parasite tissue when ivermectin works. None of us here are ivermexperts though!