Moderna mRNA sequence released to GitHub [pdf]
1–10 of 389 posts
Re: Moderna mRNA sequence released to GitHub [pdf]
#2What are the purple and blue sections after the stop codon for? I read a little about the 3' region, but for the vaccine, are these sections taken from a particular natural human sequence, or specially engineered for something else?
Re: Moderna mRNA sequence released to GitHub [pdf]
#3People joked a lot about "injectible source code / machine code" but it is kind of interesting injecting yourself with something that has the source on github.
Re: Moderna mRNA sequence released to GitHub [pdf]
#4People joked a lot about "injectible source code / machine code" but it is kind of interesting injecting yourself with something that has the source on github.
We aren’t that different from machines, we just need to know more about the CPU and all the co-processors and how the logic gates interact
But for now we can inject code to trigger protein configuration via the immune system
Re: Moderna mRNA sequence released to GitHub [pdf]
#5I’m a little confused by the title? Looking at the document, it seems to me (knowing next to nothing about this field) it includes both Pfizer and Moderna’s protein spike sequence in figures 1 and 2, respectively. Is that correct?
It’s also interesting the way it’s worded: that the sequence was “assembled from $vaccine”. Does that mean whoever published this has backed into these sequences rather than having gathered this information directly from the source(s)?
Re: Moderna mRNA sequence released to GitHub [pdf]
#6Related: Here's a article from late last year describing and explaining the source code of Pfizer vaccine:
https://berthub.eu/articles/posts/reverse-engineering-source...
It's a very interesting read and I hope the author makes another post explaining the differences of the two mrna vaccines.
Re: Moderna mRNA sequence released to GitHub [pdf]
#7People joked a lot about "injectible source code / machine code" but it is kind of interesting injecting yourself with something that has the source on github.
We aren’t that different from machines, we just need to know more about the CPU and all the co-processors and how the logic gates interact But for now we can inject code to trigger protein configuration via the immune system
Does that mean a cytokine storm is the equivalent of a buffer overflow or a DoS?
Re: Moderna mRNA sequence released to GitHub [pdf]
#8What are the purple and blue sections after the stop codon for? I read a little about the 3' region, but for the vaccine, are these sections taken from a particular natural human sequence, or specially engineered for something else?
That’s the copyright notice.
Re: Moderna mRNA sequence released to GitHub [pdf]
#9People joked a lot about "injectible source code / machine code" but it is kind of interesting injecting yourself with something that has the source on github.
Just because you see the RNA/DNA sequence on Github doesn't mean anything, DNA sequencing has been around since at least the early 70s [0]. Many pharmaceutical drugs already employ such techniques.
Re: Moderna mRNA sequence released to GitHub [pdf]
#10What are the purple and blue sections after the stop codon for? I read a little about the 3' region, but for the vaccine, are these sections taken from a particular natural human sequence, or specially engineered for something else?
It's the 3' (3-prime) UTR (un-translated region). It can affect the translation of the mRNA.
https://en.wikipedia.org/wiki/Three_prime_untranslated_regio....
The next thing is the poly-A tail:
https://en.wikipedia.org/wiki/Polyadenylation
blasting the 3' UTR, we see it ~50% of it was copied from the human mitochondria
tldr, extra regulatory signals (often not well understood)