BioNTech CEO applies Covid-19 vaccine's mRNA tech to multiple sclerosis
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Re: BioNTech CEO applies Covid-19 vaccine's mRNA tech to multiple sclerosis
#2I came up with the same idea for treating autoimmune disease years ago - in my first year of med school, actually. Back then the platform for doing this elegantly via mRNA didn't really exist, though, and I didn't want to drop out of med school to spend a half-decade or more in grad school proving the concept the clumsy way.
I'm really glad that it's finally come to fruition, but I definitely feel a bit of regret that I have come to embody the "ideas are cheap, execution matters" truism.
Re: BioNTech CEO applies Covid-19 vaccine's mRNA tech to multiple sclerosis
#3I came up with the same idea for treating autoimmune disease years ago - in my first year of med school, actually. Back then the platform for doing this elegantly via mRNA didn't really exist, though, and I didn't want to drop out of med school to spend a half-decade or more in grad school proving the concept the clumsy way. I'm really glad that it's finally come to fruition, but I definitely feel a bit of regret tha…
Please provide a link to your thesis.
Re: BioNTech CEO applies Covid-19 vaccine's mRNA tech to multiple sclerosis
#4That undismissible popup that comes up on this page is the bane of my existence
Re: BioNTech CEO applies Covid-19 vaccine's mRNA tech to multiple sclerosis
#5I came up with the same idea for treating autoimmune disease years ago - in my first year of med school, actually. Back then the platform for doing this elegantly via mRNA didn't really exist, though, and I didn't want to drop out of med school to spend a half-decade or more in grad school proving the concept the clumsy way. I'm really glad that it's finally come to fruition, but I definitely feel a bit of regret tha…
Don't feel too bad, the execution depended on a massive world-changing pandemic where funding flowed freely and normal economics just didn't apply.
Re: BioNTech CEO applies Covid-19 vaccine's mRNA tech to multiple sclerosis
#6Can anyone comment on where we would be if COVID-19 hit a few years earlier and mRNA wasn't ready for primetime?
Re: BioNTech CEO applies Covid-19 vaccine's mRNA tech to multiple sclerosis
#7Great news! I wonder how much industry resistance there will be. Treating MS patients is a massive industry. Drug treatments are $100k a year currently, replacing that with a single $20 vaccine would be disruptive in the best way.
Re: BioNTech CEO applies Covid-19 vaccine's mRNA tech to multiple sclerosis
#8I've re-read the article a couple of times but I'm having trouble understanding how this works. I understand how an mRNA vaccine can teach the immune system to recognize a virus, but in the case of an autoimmune disorder, the challenge is to teach the immune system to stop attacking something, right?
How can an mRNA vaccine cause the immune system to "forget" something that it thinks is harmful?
Re: BioNTech CEO applies Covid-19 vaccine's mRNA tech to multiple sclerosis
#9Can anyone comment on where we would be if COVID-19 hit a few years earlier and mRNA wasn't ready for primetime?
Pretty screwed for at least another year.
Re: BioNTech CEO applies Covid-19 vaccine's mRNA tech to multiple sclerosis
#10Can anyone comment on where we would be if COVID-19 hit a few years earlier and mRNA wasn't ready for primetime?
Using a vaccine created by one of the many other mechanisms that are in the pipeline, like the Oxford or J&J vaccines.
https://www.nytimes.com/interactive/2020/science/coronavirus...